PMID: 2505886Jul 24, 1989Paper

Effect of dopaminergic denervation and transplant-derived reinnervation on a marker of striatal GABAergic function

Brain Research
J SegoviaK Gale

Abstract

Solid grafts of dopamine-containing fetal mesencephalon were placed adjacent to the striatum of rats with 6-hydroxydopamine lesions of ascending dopaminergic projections. These grafts resulted in a significant, although partial, reversal of the lesion-induced increase in striatal glutamic acid decarboxylase (GAD) when measured 3-4 months after the lesion. These results suggest that the grafted neurons can partly restore inhibitory control over striatal GABA neurons. In the same rats, the grafts partially reversed apomorphine-induced turning although amphetamine-induced turning was nearly abolished. It is likely that both apomorphine-induced behavior and striatal GAD activity reflect the sustained chronic influence of the graft on target neurons in striatum.

References

Nov 1, 1970·Journal of Neurochemistry·K L Sims, F N Pitts

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Citations

Aug 1, 1993·Journal of Neuroscience Methods·C P LawlerR B Mailman
Sep 1, 1994·Progress in Neurobiology·J P Herman, N D Abrous
Mar 1, 1994·Cell Transplantation·A Fine
Jan 1, 1992·Cell Transplantation·D F EmerichP R Sanberg

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