PMID: 6172180Dec 28, 1981Paper

Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cord

Brain Research
M NinkovicJ S Kelly

Abstract

The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both neurotensin and opiate receptors were found within the superficial layers of the spinal cord, paralleling the distribution of neurotensin and enkephalin-containing interneurons and nerve terminals. Dorsal root section produced a 40% loss of opiate receptors throughout layers I and II of the spinal cord whilst no change in neurotensin receptor density or distribution was found. At the electron microscopic level the presence of neurotensin-like immunoreactivity within vesicle-containing profiles in the dorsal horn was demonstrated; however, no interaction of these terminals with primary afferent boutons was seen.

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Citations

May 26, 1999·The Journal of Comparative Neurology·H N Wenk, C N Honda
May 23, 1983·Brain Research·P Stanzione, W Zieglgänsberger
Oct 11, 1988·European Journal of Pharmacology·M R DashwoodK M Spyer
May 1, 1989·Trends in Pharmacological Sciences·J SawynokT D White
Oct 1, 1985·Behavioural Brain Research·D van der Kooy, J I Nagy
Jul 1, 1983·Peptides·J L Hylden, G L Wilcox
Mar 28, 1983·Neuroscience Letters·R Gamse, S Heuberger
Oct 1, 1985·Neuroscience·J L MaderdrutR W Oppenheim
Aug 1, 1987·Neuroscience·J K MaiJ Metz
Jun 1, 1997·Brain Research. Brain Research Reviews·R E Coggeshall, S M Carlton

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