Effect of dose rate on the radiation-induced bystander response

Physics in Medicine and Biology
M D GowCarmel E Mothersill

Abstract

Radiation-induced biological bystander effects have become a well-established phenomenon associated with the interaction of radiation with cells. These so-called bystander effects have been seen across a variety of end points for both high and low linear energy transfer (LET) radiations, utilizing a variety of dose rates and radiation sources. In this study, the effect of dose rate and different low LET sources on the bystander cell survival fraction (SF) was examined. The cell line investigated was the human keratinocyte HPV-G. The bystander response was measured via clonogenic assay after medium transfer protocol. Cells were irradiated using (60)Co gamma-rays and 20 MeV electrons at doses of 0.5, 5 and 10 Gy with varying dose rates. Both gamma and electron irradiation decreased recipient SF at 0.5 Gy and 5 Gy, respectively. Subsequent recovery of the SF to control levels for 10 Gy was observed. There was no dose rate dependence for (60)Co irradiation. A significant difference in the survival fraction was observed for electron irradiation at 10 Gy and a high dose rate. Furthermore, survival fractions were compared between (60)Co and 20 MeV electron irradiations. This showed a significant increase in the survival fraction 'reco...Continue Reading

References

Mar 1, 1977·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R J Purrott, E J Reeder
Jul 1, 1975·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D C LloydM J Corp
Feb 1, 1994·The Journal of Clinical Investigation·M H Barcellos-HoffJ A Weatherbee
Oct 23, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E J EhrhartM H Barcellos-Hoff
Jan 9, 1999·International Journal of Radiation Biology·K M PriseB D Michael
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·H ZhouT K Hei
May 4, 2000·The New England Journal of Medicine·G C BlobeH F Lodish
Jul 6, 2000·Advances in Immunology·K MiyazonoC H Heldin
Jan 4, 2001·Journal of Dermatological Science·K Hashimoto
Feb 22, 2001·Radiation Research·H MatsumotoE Kano
May 16, 2001·Radiation Research·C Mothersill, C Seymour
Jan 5, 2002·Radiation Research·Rashi Iyer, Bruce E Lehnert
Mar 15, 2002·Radiation Research·S G SawantE J Hall
Apr 23, 2002·Radiation Research·Carmel MothersillM C Joiner
Oct 19, 2002·Radiation Research·Carmel Mothersill, C B Seymour
May 27, 2003·Journal of Cellular Physiology·Charles E Wenner, Shaochun Yan
Jul 11, 2003·Health Physics·Eric J Hall
Aug 16, 2003·Radiation and Environmental Biophysics·Chunlin ShaoYoshiya Furusawa
May 1, 1956·The Journal of Experimental Medicine·T T PUCK, P I MARCUS
Oct 29, 2003·Radiation Protection Dosimetry·K M PriseB D Michael
Feb 26, 2004·Radiation Research·Carmel MothersillC B Seymour
Sep 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chunlin ShaoKevin M Prise
Sep 14, 2004·International Journal of Radiation Biology·S A MitchellE J Hall
Mar 10, 2005·International Journal of Cancer. Journal International Du Cancer·Chunlin ShaoKevin M Prise
Jul 30, 2005·Medicine, Conflict, and Survival·Carmel Mothersill, Colin Seymour
Sep 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Oleg V BelyakovDavid J Brenner
Jan 18, 2006·Mutation Research·John B Little
Jul 1, 2006·Radiation Research·Zhengfeng LiuWilliam V Prestwich
Jul 19, 2006·International Journal of Radiation Biology·Fiona M LyngKevin M Prise
Feb 13, 2007·Environmental Research·R C C PoonC Mothersill

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Citations

Sep 22, 2010·Australasian Physical & Engineering Sciences in Medicine·Svetlana Sjostedt, Eva Bezak
Mar 29, 2012·Australasian Physical & Engineering Sciences in Medicine·Elizabeth Claridge MackonisDavid R McKenzie
Jul 16, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·K T ButterworthK M Prise
Apr 21, 2009·Nature Reviews. Cancer·Kevin M Prise, Joe M O'Sullivan
May 30, 2014·Journal of Medical Physics·Shokouhozaman SoleymanifardShokoufeh Mohebbi
May 16, 2013·Radiation and Environmental Biophysics·Carmel Mothersill, Colin Seymour
Oct 22, 2013·Cancer Letters·Alessandro CampaMaria Antonella Tabocchini
Jun 3, 2009·Mutation Research·Rajalakshmi S AsurJames D Tucker
Feb 27, 2016·International Journal of Radiation Biology·Chandan KumarBadri N Pandey
Mar 25, 2014·Dose-response : a Publication of International Hormesis Society·M D GowC E Mothersill
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Hayley FurlongOrla Howe
Nov 30, 2018·International Journal of Radiation Biology·Sharmi Mukherjee, Anindita Chakraborty
May 13, 2020·International Journal of Radiation Biology·Lukasz LaskowskiCarmel Mothersill
Jan 9, 2013·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·V W Y ChoiK N Yu
Aug 7, 2017·Radiation and Environmental Biophysics·Nguyen T K VoCarmel E Mothersill
Jun 19, 2019·Dose-response : a Publication of International Hormesis Society·Nguyen T K VoCarmel E Mothersill
Feb 13, 2013·Physics in Medicine and Biology·R B KingA R Hounsell
Jan 4, 2021·Cellular and Molecular Life Sciences : CMLS·Raghda RamadanLuc Leybaert

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