PMID: 39988Aug 1, 1979

Effect of drug content and drug particle size on the change in particle size during tablet compression

The Journal of Pharmacy and Pharmacology
N Kitamori, T Makino


Three size fractions for each of three poorly soluble drugs were compressed into 10 mm diameter tablets of four different dilution ratios. The compression was carried out on a physical testing instrument at four compression levels of 49.0, 98.1, 196.2 and 294.3 MN m-2. The effect of drug content and drug particle size on the change in particle size during tableting was examined by the determination of the dissolution rate for disintegrated tablets. A linear relation was obtained when plotting 1n(T80%) versus drug content. There was a critical particle size where the phenomena of cleavage and bonding during tableting balanced each other, but this varied with drug content.


Jan 1, 1976·The Journal of Pharmacy and Pharmacology·J R Carless, A Sheak
Aug 1, 1979·The Journal of Pharmacy and Pharmacology·N Kitamori, T Makino

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Drug Formulation Process
Particle Size

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