PMID: 22569433May 10, 2012Paper

Effect of duration on hemodialysis on prevalence of Helicobacter pylori infection

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Yousef RasmiKhadijeh Makhdomi

Abstract

Digestive tract complications are common in hemodialysis (HD) patients, and Helicobacter pylori (H. pylori) is thought to play an important role in the pathogenesis of gastrointestinal mucosal lesions in these patients. Also, reports indicate that cytotoxin-associated gene A (CagA) is the major factor involved in the pathogenesis of H. pylori disease. However, many issues regarding H. pylori infection in HD patients are still unclear. In this cross-sectional study, we investigated the effect of duration on HD on the prevalence of H. pylori infection and its virulent CagA(+) strain. One-hundred and fifty-one HD patients who were referred to our university HD center were included in the study. There were 78 males and 73 females, with a mean age of 54.2 ± 14.6 years (range: 19-87 years). They were tested for serum anti-H. pylori IgG antibody by the enzyme-linked immunosorbent assay method. Also, anti-CagA IgG antibody was tested in H. pylori-infected patients. The study patients were categorized into two groups: short-term HD duration (STHD: ≤3 years) and long-term HD duration (LTHD: >3 years). The overall prevalence of antibodies to H. pylori and CagA were 65.6% (99/151) and 25.3% (25/99), respectively. The prevalence of H. pylor...Continue Reading

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