Effect of dutasteride on intraprostatic androgen levels in men with benign prostatic hyperplasia or prostate cancer

Urology
Roger RittmasterR Wurzel

Abstract

Dutasteride exerts its beneficial effects on the prostate through suppression of intraprostatic dihydrotestosterone (DHT). The aim of this analysis was to assess the effects of the approved dose of dutasteride (0.5 mg/d), given for 2 weeks to 4 months, on the serum and intraprostatic DHT and testosterone levels in 3 randomized studies. Intraprostatic androgen levels were measured in benign prostatic tissue collected during transurethral resection of the prostate (benign prostatic hyperplasia studies, n = 256) or radical prostatectomy (prostate cancer study, n = 51), performed after 2 weeks, or 1, 3, or 4 months of treatment with dutasteride or with placebo or surgery alone. The serum androgen levels were assessed at the same points during treatment. Data from the control groups were pooled to provide 1 comparison group. Dutasteride reduced the intraprostatic DHT levels by 83%, 90%, 92%, and 93% after 2 weeks and 1, 3, and 4 months of treatment, respectively, compared with placebo/surgery alone. Dutasteride reduced the serum DHT levels from baseline by 84% at 2 weeks and by approximately 90% at 1, 2, 3, and 4 months compared with a 5.2% increase in the control group. The decrease in DHT levels with dutasteride was accompanied by...Continue Reading

References

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Citations

Jan 11, 2014·Asian Journal of Andrology·Lori A Cooper, Stephanie T Page
Apr 1, 2014·Sexual Medicine Reviews·J Curtis Nickel, Culley C Carson
Feb 10, 2009·European Urology·Roger S RittmasterIan M Thompson
Jul 3, 2013·Journal of Clinical Pharmacy and Therapeutics·Y K LokeS Singh
Jun 20, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro Maeda
Oct 24, 2013·The Prostate·Mark A TitusJames L Mohler
Sep 10, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Steven PhamEmma S Tomlinson Guns
Oct 18, 2014·Prostate International·Inna ArmandariJack Schalken
Jan 25, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Chaeyong JungTaek Won Kang
Oct 19, 2013·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kazuyoshi ShigeharaMikio Namiki
Apr 9, 2017·Cold Spring Harbor Perspectives in Medicine·Charles DaiNima Sharifi
Oct 5, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro MaedaMototsugu Oya
Aug 28, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Marta Martín-FernándezConcepción De la Piedra
Aug 30, 2018·Nature Reviews. Urology·Vaibhav PatelWilliam Oh
Jun 21, 2015·Molecular and Cellular Biochemistry·Suruchi AggarwalTapas Mukhopadhyay
Aug 11, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alan R KristalAnn W Hsing
Nov 6, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mary-Ellen TaplinSteven P Balk

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