Effect of Dynamic Changes in Anterior Cruciate Ligament In Situ Graft Force on the Biological Healing Response of the Graft-Tunnel Interface

The American Journal of Sports Medicine
Richard MaScott A Rodeo

Abstract

Anterior cruciate ligament (ACL) grafts that are placed for reconstruction are subject to complex forces. Current "anatomic" ACL reconstruction techniques may result in greater in situ graft forces. The biological effect of changing magnitudes of ACL graft force on graft-tunnel osseointegration is not well understood. The research objective is to determine how mechanical force on the ACL graft during knee motion affects tendon healing in the tunnel. Controlled laboratory study. Male rats (N = 120) underwent unilateral ACL reconstruction with a soft tissue flexor tendon autograft. ACL graft force was modulated by different femoral tunnel positions at the time of surgery to create different graft force patterns with knee motion. External fixators were used to eliminate graft load during cage activity. A custom knee flexion device was used to deliver graft load through controlled daily knee motion. Graft-tunnel healing was then assessed via biomechanical, micro-computed tomography, and histological analyses. ACL graft-tunnel healing was sensitive to dynamic changes in graft forces with postoperative knee motion. High ACL graft force with joint motion resulted in early inferior ACL graft load to failure as compared with knees that ...Continue Reading

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Citations

Dec 2, 2020·The American Journal of Sports Medicine·Sebastian Cardona-RamirezRichard Ma
May 18, 2021·The American Journal of Sports Medicine·Junjie XuJinzhong Zhao
Jul 11, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Ahmet Emin OkutanOsman Aynacı

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Methods Mentioned

BETA
force measurements
pullout
pull-out

Software Mentioned

LabView
SPSS Statistics
Excel

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