Effect of early correction of anemia on the progression of CKD

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Jérôme RossertWilliam McClellan

Abstract

This study is designed to assess the effect of early and complete correction of anemia by using recombinant human erythropoietin (epoetin) alfa on the progression of chronic kidney disease (CKD). Patients were randomly assigned to achieve high (13 to 15 g/dL [130 to 150 g/L]) or low (11 to 12 g/dL [110 to 120 g/L]) hemoglobin-level targets during 4 months of stabilization, followed by 36 months of maintenance. Glomerular filtration rate (GFR) decrease was measured by using iohexol clearance. Quality of life, nutrition, and safety also were monitored. Because of labeling changes for subcutaneous administration of epoetin alfa (Eprex; Johnson and Johnson, Schaffhausen, Switzerland), the study was terminated prematurely. There were 195 patients enrolled in each group; 108 high-hemoglobin and 133 low-hemoglobin patients entered the maintenance phase. Mean maintenance duration was 7.4 months for the high-hemoglobin group and 8.3 months for the low-hemoglobin group. GFR decrease was numerically, but not statistically significantly, lower with the high-hemoglobin group (0.058 versus 0.081 mL/min/1.73 m2/mo [< 0.01 mL/s/1.73 m2/mo]). Physical quality-of-life measures showed trends (Role-Physical, P = 0.055; Physical Function, P = 0.083...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jul 1, 1992·American Journal of Hypertension·A L KamperP P Leyssac
Jan 1, 1990·American Journal of Nephrology·P A AbrahamC E Halstenson
Dec 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K S KleinmanR I Abels
Jun 23, 1988·The New England Journal of Medicine·S KlahrI Ichikawa
Nov 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen
Aug 1, 1995·Journal of the American Society of Nephrology : JASN·F GaspariG Remuzzi
Oct 1, 1994·BMJ : British Medical Journal·T HannedoucheJ M Suo
Nov 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D RothC A Shadur
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L P McMahonG J Becker
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P JungersN K Man
Feb 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jerome RossertDierik L Verbeelen
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brian A J WaltersWilliam B Carter
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jan 25, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans FurulandBo G Danielson
Feb 7, 2003·Journal of the American College of Cardiology·Guruprasad ManjunathMark J Sarnak
Mar 13, 2003·Kidney International·William F KeaneUNKNOWN RENAAL Study Investigators
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Steven J ChadbanRobert C Atkins
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Jerome RossertJean Jacques Boffa
Aug 7, 2003·The Lancet Oncology·Brian Leyland-Jones, UNKNOWN BEST Investigators and Study Group
Jun 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco LocatelliUNKNOWN European Best Practice Guidelines Working Group
Sep 24, 2004·Current Medical Research and Opinion·William McClellanMarc Leiserowitz
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Oct 2, 2004·The New England Journal of Medicine·Charles L BennettNicole Casadevall
May 20, 2005·Journal of the American Society of Nephrology : JASN·Patrick S ParfreyDieter Frei
Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Danilo FliserEberhard Ritz

❮ Previous
Next ❯

Citations

Jun 30, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jérôme HarambatE Jane Tizard
Nov 17, 2006·The New England Journal of Medicine·Giuseppe Remuzzi, Julie R Ingelfinger
Nov 17, 2006·The New England Journal of Medicine·Ajay K SinghUNKNOWN CHOIR Investigators
Mar 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gisela SturmFlorian Kronenberg
Feb 10, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roberto MinutoloLuca De Nicola
Jan 22, 2010·Current Opinion in Pediatrics·Amy Staples, Craig Wong
Oct 4, 2007·Osteopathic Medicine and Primary Care·Rebecca J Schmidt, Cheryl L Dalton
May 14, 2009·Therapeutics and Clinical Risk Management·Iain Rj MacphersonNicholas S Reed
May 20, 2008·Therapeutics and Clinical Risk Management·Francesco LocatelliLucia Del Vecchio
Oct 23, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roberto MinutoloUNKNOWN REport of COmorbidities in non-Dialysis Renal Disease Population in Italy (RECORD-IT) Study Group
Jun 29, 2007·Kidney International·S Fishbane, A R Nissenson
Aug 28, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ioannis KoulouridisBertrand L Jaber
Apr 28, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jula K InrigLynda A Szczech
Nov 21, 2007·Kidney International. Supplement·K Iseki, K Kohagura
May 24, 2011·Journal of Diabetes and Its Complications·Emmanuel VillarClaire Pouteil-Noble
Jan 11, 2011·Néphrologie & thérapeutique·Gabriel ChoukrounMaïté Jauréguy
Dec 25, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shravanthi R GandraMona L Martin
May 23, 2009·Medicina clínica·A CasesS Collado
Feb 24, 2009·Advances in Chronic Kidney Disease·Anatole BesarabJerry Yee
Nov 13, 2008·Néphrologie & thérapeutique·Tilman B Drüeke
Sep 2, 2008·Heart Failure Clinics·Steven Fishbane
Aug 5, 2008·The American Journal of Geriatric Pharmacotherapy·Marcia R SilverCatherine Stehman-Breen
Jul 1, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Katrina Louise CampbellJudith Dorothea Bauer
Dec 7, 2007·La Revue de médecine interne·A BaglinL Moulonguet-Doleris
Aug 28, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN KDOQI
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eberhard RitzUNKNOWN Anemia Correction in Diabetes Study Investigators
Sep 5, 2006·Seminars in Nephrology·Jerome Rossert, Marc Froissart
Oct 12, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fiona M ClementBraden J Manns
Sep 2, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Nattachai SrisawatSomchai Eiam-Ong
Jun 9, 2007·Seminars in Dialysis·Jeffrey S Berns, Steven Fishbane
Jan 27, 2007·European Journal of Haematology·Wolfgang Jelkmann
Apr 16, 2008·British Journal of Haematology·Wolfgang Jelkmann
Mar 28, 2012·Journal of Renal Care·P E Stevens
Oct 7, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tadao AkizawaUNKNOWN KRN321 STUDY Group
May 18, 2010·Nephrology·Suetonia C PalmerGiovanni F M Strippoli
Mar 24, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bradley A WaradySusan Furth
Jul 1, 2009·Diabetes Care·Uzma Mehdi, Robert D Toto
Dec 9, 2014·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli

❮ Previous
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