Effect of early initiation of highly active antiretroviral therapy on CD4 cell count and HIV-RNA viral load trends within 24 months of the onset of acute retroviral syndrome

HIV Medicine
N VoirinPhilippe Vanhems

Abstract

The effect of starting highly active antiretroviral therapy (HAART) early after the onset of acute retroviral syndrome (ARS) on CD4 and HIV-RNA trends was studied over a 2-year follow-up period. Four groups of HIV-infected patients stratified according to the time interval from ARS onset to HAART initiation and a control group of untreated patients were compared. The results indicated that the earlier the start of HAART, the faster was the rate of CD4 increase and HIV-RNA decrease. However, this difference did not seem to persist at 24 months. The optimal treatment strategy for HIV-infected patients needs to be explored further.

References

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Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·A OxeniusR E Phillips
Jul 26, 2006·Pharmacotherapy·Frank J Piacenti
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Aug 31, 2006·The Journal of Infectious Diseases·Hendrik StreeckMarcus Altfeld
Mar 3, 2007·The Journal of Infectious Diseases·Bluma G BrennerUNKNOWN Quebec Primary HIV Infection Study Group

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