Effect of early isolation on the synaptic function in the dentate gyrus and field CA1 of the guinea pig

Hippocampus
R Bartesaghi

Abstract

We previously reported that neonatal isolation shapes neuron morphology remarkably in the dentate gyrus and hippocampus of the guinea pig, a precocial rodent whose brain is at an advanced stage of maturation at birth. The aim of the present work was to investigate the effects of early isolation on the physiology of the hippocampal trisynaptic circuit. Male and female guinea pigs were assigned at 6-7 days of age to either a social or an isolated environment. After 90-100 days, the animals were anesthetized and electrophysiological experiments were carried out. The monosynaptic response evoked by medial perforant path stimulation in the dentate gyrus (DG) and the following response trisynaptically evoked in field CA1 by the DG-CA3 system were evaluated with several stimulus protocols: (1) current source-density (CSD) analysis; (2) input/output function; (3) paired-pulse potentiation (PPP); and (4) long-term potentiation (LTP). Isolated animals exhibited a reduction in the magnitude of the current sinks in the middle molecular layer and granule cell layer of the DG and in the input/output function of the granule cell population excitatory postsynaptic potential (EPSP) and population spike (PS) over a wide range of stimuli. The lat...Continue Reading

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Citations

Jan 30, 2009·Journal of Cellular and Molecular Medicine·Sanja DarmopilNenad Bogdanović
Dec 5, 2006·Hippocampus·Simona RizziRenata Bartesaghi
Aug 10, 2012·Seizure : the Journal of the British Epilepsy Association·Rafael Scarpa da Costa NevesElza Márcia Targas Yacubian
Jul 6, 2010·Arquivos de neuro-psiquiatria·Itala Mônica de Sales SantosRivelilson Mendes de Freitas
Jan 21, 2018·Scientific Reports·Roberta NarducciLamberto Maffei

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