PMID: 2119442Jul 1, 1990Paper

Effect of early postoperative nutritional support on skin wound and colon anastomosis healing

JPEN. Journal of Parenteral and Enteral Nutrition
H M DelanyS M Levenson

Abstract

Improved healing occurs in nutritionally depleted rats given early postoperative compared with delayed feeding. The present study was designed to test the hypothesis that delay in postoperative feeding of rats normally nourished at the time of operation would also be detrimental to wound healing. Fully nourished rats weighing 288 to 342 g were divided into three groups (10 rats per group). All rats had central vein catheters inserted, celiotomy with division and reanastomsis of the colon and dorsal skin incisions, under ip pentobarbital anesthesia. With no oral intake allowed postoperatively, group 1 rats were maintained in iv 5% Dextrose electrolytes and vitamins (5% DSV); group 2 was given the 5% D/SV until the third postoperative day when they were placed on TPN (4.5% amino acids 15% Dextrose, 10% Intralipids); and group 3 was given TPN from the first postoperative day. Rats were sacrificed 6 days postoperatively and final weight, skin wound breaking strength (WBS) and colon anastomosis bursting pressure (CBP) were measured. Findings were % weight change -27.8 +/- 1.5 for Group 1, -12.6 +/- 1.0 for Group 2, and -6.9 +/- 8 for group 3 (p less than 0.0001). Wound measurements for STS on fresh specimens were 88.6 +/- 10.0 g for...Continue Reading

References

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Citations

Dec 1, 1994·Diseases of the Colon and Rectum·A J BufoR C Lieberman
Oct 1, 1993·British Journal of Plastic Surgery·P H JørgensenT T Andreassen
Feb 13, 2002·American Journal of Surgery·T M KhaliliD R Margulies
Jan 1, 1997·APMIS. Supplementum·P H Jørgensen
Mar 17, 1999·Heart & Lung : the Journal of Critical Care·J D Whitney, M M Heitkemper
Jun 1, 1997·The Surgical Clinics of North America·T K Hunt, H W Hopf
Mar 9, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M-T LinW-J Chen
Jun 28, 2011·American Journal of Obstetrics and Gynecology·James Fanning, Fidel A Valea
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Cheryl Thompson, M Patricia Fuhrman
May 4, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nidhi MalhotraRadhika B Agarwala
Jul 1, 1994·Journal of Pediatric Surgery·D MistryD Parks
Aug 9, 2003·Critical Care Medicine·Maria B Witte, Adrian Barbul
Mar 11, 1998·The Australian and New Zealand Journal of Surgery·B T StewartJ O Keck
Sep 2, 1992·Journal of Wound Care·S M G McLaren
Jul 25, 1998·Diseases of the Colon and Rectum·T M KhaliliE H Phillips
Jun 1, 1997·The Surgical Clinics of North America·F J Thornton, A Barbul

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