PMID: 8988926Jan 1, 1997Paper

Effect of early vitamin A supplementation on cell-mediated immunity in infants younger than 6 mo

The American Journal of Clinical Nutrition
M M RahmanD Habte

Abstract

One hundred twenty infants were randomly assigned to receive either 15 mg vitamin A or placebo with each of three DPT/OPV (diphtheria, pertussis, tetanus/oral polio vaccine) immunizations at monthly intervals. Sixty-two received vitamin A and 58 received placebo. One month after the third supplementation dose, the response to the delayed cutaneous hypersensitivity test [multitest cell-mediated immunity (CMI) skin evaluation] for tetanus, diphtheria, and tuberculin (purified protein derivative, PPD) was the same in the vitamin A and placebo infants. The number of anergic infants was 17 (27%) and 19 (33%) in the vitamin A and placebo groups, respectively. The number of positive tests among well-nourished infants was significantly higher than that in malnourished infants irrespective of supplementation (P < 0.001). Among the infants with adequate serum retinol concentrations (> 0.7 mumol/L) after supplementation, the vitamin A-supplemented infants had a significantly higher proportion of positive CMI tests than the placebo infants (chi-square test: 8.99, P = 0.008). Among the infants with low serum retinol concentrations (< 0.7 mumol/L) after supplementation, vitamin A supplementation had no effect on CMI response. These results i...Continue Reading

Citations

Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·L BrabinB Brabin
Jul 16, 2005·Clinical Microbiology Reviews·Eduardo Villamor, Wafaie W Fawzi
Oct 16, 2003·International Journal of Epidemiology·Christine Stabell BennPeter Aaby
May 26, 2001·Annual Review of Nutrition·C B Stephensen
Dec 6, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Kristoffer J JensenKatie L Flanagan
Dec 22, 1999·The Proceedings of the Nutrition Society·R D Semba
Sep 30, 2016·The Cochrane Database of Systematic Reviews·Aamer ImdadZulfiqar A Bhutta
Aug 30, 2007·Annals of Nutrition & Metabolism·Eva S WintergerstDietrich H Hornig
Oct 24, 2020·Nutrients·Francesco PecoraSusanna Esposito
Mar 7, 2021·International Journal of Molecular Sciences·Giuseppe Fabio ParisiSalvatore Leonardi

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