Effect of edaravone on favorable outcome in patients with acute cerebral large vessel occlusion: subanalysis of RESCUE-Japan Registry

Neurologia Medico-chirurgica
Yuki MiyajiYusuke Tomogane

Abstract

The data of the nationwide prospective registry of acute cerebral large vessel occlusion (LVO; RESCUE-Japan Registry) were analyzed to know the effect of edaravone, a free radical scavenger, on clinical outcome at 90 days after onset. In this registry, patients with acute cerebral LVO admitted within 24 h after onset were prospectively registered. The effect of various factors including endovascular treatment (EVT), intravenous recombinant tissue plasminogen activator (IV rt-PA), and other medication including edaravone on favorable outcome (modified Rankin scale 0-1) was analyzed. Of the 1,454 registered patients, 1,442 patients (99.2%) had the information of edaravone were analyzed. In total, edaravone group had more patients with favorable outcome compared to non-edaravone group (22.9% vs. 13.8%, p = 0.0006). Edaravone increased favorable outcome in patients treated with IV rt-PA (29.4% vs. 11.1%, p = 0.0107), but not with EVT (21.2% vs. 13.9%, p = 0.309). Logistic regression analysis revealed that higher National Institutes of Health Stroke Scale (NIHSS) score on admission [odds ratio (OR) 0.875, 95% confidence interval (CI) 0.858-0.894] and advanced age (OR 0.963, 95%CI 0.952-0.975) were significantly related to unfavorabl...Continue Reading

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Citations

Dec 21, 2017·Oxidative Medicine and Cellular Longevity·Kiyoshi KikuchiIkuro Maruyama
May 16, 2018·Stroke; a Journal of Cerebral Circulation·Atsushi MizumaMidori A Yenari
Aug 30, 2020·Pharmacological Reviews·Ana I CasasHarald H H W Schmidt
Aug 8, 2018·Therapeutic Advances in Neurological Disorders·Antoine DrieuMarina Rubio
Sep 25, 2017·Frontiers in Neurology·Atsushi Mizuma, Midori A Yenari
Jun 20, 2020·Drugs in R&D·Paul C MacklisBenjamin H Kaffenberger
Jun 21, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chengdi LiuGuanhua Du
Nov 28, 2019·Organic Letters·Guodong JuYingsheng Zhao
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biswadeep DasAkash Agnihotri

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