PMID: 7538411Jan 1, 1995Paper

Effect of EGF on rat parotid gland secretory function

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
K R PurushothamM G Humphreys-Beher

Abstract

The present study reports changes in saliva composition from the rat parotid gland in response to single and repeated administration of epidermal growth factor (EGF). Treatment of rats with EGF (10 micrograms/kg, i.p., twice daily for 3 days) caused an increase in amylase activity in saliva collected from cannulated parotid duct, following stimulation of secretion with pilocarpine, with a corresponding decrease in enzyme activity in the gland. Analysis of parotid gland RNA by reverse transcriptase-PCR generated a single predicted amylase-derived cDNA product of 576 bp. The steady-state levels of mRNA for amylase from EGF-treated parotid total RNA showed a 1.8-fold increase compared to untreated controls. A single dose of EGF (15 min following i.p. injection) elicited an activation of both protein kinase A and protein kinase C activities. While the activation of protein kinase A was still maintained under the chronic EGF regimen, the activity levels of protein kinase C showed down-regulation to untreated control values.

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Citations

Jun 29, 2005·Annals of Biomedical Engineering·Taili T ThulaChristopher Batich
Aug 20, 2011·Science·Karen P Day, Freya J I Fowkes
Jun 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David L SmithAndrew J Tatem
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K R Purushotham, M G Humphreys-Beher
Jan 24, 2003·American Journal of Physiology. Cell Physiology·Chih-Ko YehMichael S Katz
Sep 26, 2000·American Journal of Physiology. Cell Physiology·B X ZhangM S Katz

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