PMID: 8964757Mar 1, 1996Paper

Effect of eicosanoid inhibition on the development of pulmonary edema after acute lung injury

Journal of Applied Physiology
D P SchusterP Sandiford

Abstract

In experimental models of acute lung injury, cyclooxygenase inhibition improves oxygenation, presumably by causing a redistribution of blood flow away from edematous lung regions. This effect on perfusion pattern could also reduce alveolar edema formation. On the other hand, pulmonary pressures usually increase after cyclooxygenase inhibition, an effect that could exacerbate edema accumulation. Therefore we tested the following hypothesis: the total accumulation of pulmonary edema in dogs during a 24- to 28-h period of observation after acute lung injury caused by oleic acid will be less in a group of animals treated with meclofenamate (n = 6) or with the thromboxane-receptor blocker ONO-3708 (n = 5) than in a group of animals treated with oleic acid alone (placebo, n = 6). Lung water concentrations (LWC), the regional pattern of pulmonary perfusion, and protein permeability were measured with the nuclear medicine imaging technique of positron emission tomography. After 24-28 h, LWC was significantly less (P < 0.05) in the ONO-3708 group than in the meclofenamate group (a similar trend was seen compared with the placebo group, P = 0.12). After 24-28 h, pulmonary arterial pressures were highest in the meclofenamate group. Regard...Continue Reading

Citations

Feb 21, 1998·Intensive Care Medicine·D P Schuster
Jan 15, 2005·Antioxidants & Redox Signaling·Luke J JanssenPeter Helli
Apr 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ian B CoplandMartin Post
Apr 29, 2008·American Journal of Respiratory Cell and Molecular Biology·Luke J Janssen
Apr 10, 2002·Critical Care Medicine·Serge BrimioulleDaniel P Schuster
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·R GustD P Schuster
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L J Janssen
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·R GustD P Schuster
Nov 20, 2004·Journal of Applied Toxicology : JAT·Ken-ichiro InoueToshikazu Yoshikawa
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·N R LangeD P Schuster
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·R GustD P Schuster
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·M LeemanR Naeije
Mar 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alan E JonesJeffrey A Kline
Jan 22, 2002·Pediatric Pulmonology·Amir M KhanGiuseppe N Colasurdo
Aug 10, 2000·Pulmonary Pharmacology & Therapeutics·L J Janssen
Jan 11, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S D Zuijdgeest-Van LeeuwenJ H Wilson
Mar 24, 2004·Chemistry and Physics of Lipids·L J Janssen

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