PMID: 11920659Mar 29, 2002Paper

Effect of elastin on the calcification rate of collagen-elastin matrix systems

Journal of Biomedical Materials Research
Anuj Singla, Chi H Lee

Abstract

The role of elastin in the aortic wall calcification and involved mechanisms were investigated. The major hypothesis of this work is that elastin is one of the major components to regulate calcification of bioprosthetic heart valve (BHV). The relationship between the elastin content and the calcification rate of the aortic wall was established using collagen-elastin matrices (CEM) made of varying ratios of collagen and elastin (90 and 10, 50 and 50, and 20 and 80). Biophysical characterization of CEM was performed by water content measurement and the tensile strength test. The conformational changes of the calcifiable matrix were evaluated as a function of elastin content using Fourier transform infrared (FTIR) spectroscopy. The calcium contents in CEM implanted in the rat subcutaneous model for 7 days were measured using atomic absorption (AA) spectroscopy. As the concentration of elastin in CEM increased from 10 to 80%, the total amount of calcium accumulated in CEM also increased. The calcium level in CEM containing the collagen and an elastin ratio of 20:80 was 20.16 +/- 0.70 microg/mg compared with 1.96 +/- 0.04 microg/mg in CEM containing the collagen and an elastin ratio of 90:10. The calcification rate of CEM pretreated...Continue Reading

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Citations

Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·K SubburamanM Rafailovich
Dec 2, 2004·Expert Opinion on Biological Therapy·Dan T Simionescu
Mar 14, 2009·Journal of Tissue Engineering and Regenerative Medicine·Aditee Kurane, Naren Vyavahare
Sep 3, 2011·Journal of Biomedical Materials Research. Part a·Yi LiuChi H Lee
May 17, 2006·Acta Biomaterialia·M Martín MaestroE Jorge-Herrero
Jan 1, 2008·Cell Adhesion & Migration·Benjamin J Lawrence, Sundararajan V Madihally
Feb 26, 2003·Journal of Biomedical Materials Research. Part a·Anuj Singla, Chi H Lee
Jun 17, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·W M L NeethlingR Glancy
Aug 15, 2006·Journal of Biomedical Materials Research. Part a·Aliakbar MoshfeghianSundararajan V Madihally
Jun 5, 2008·Biomedical Materials·Walid A FarhatHerman Yeger
Dec 25, 2008·Macromolecular Bioscience·Xinqiao Jia, Kristi L Kiick
May 18, 2012·Biotechnology and Bioengineering·James D BryersBuddy D Ratner
Feb 29, 2020·Biomaterials Science·Barbara Kupikowska-Stobba, Dorota Lewińska
May 5, 2020·BioImpacts : BI·Maryam Sadat KhoramgahHossein Ghanbarian
Apr 11, 2006·Biomacromolecules·Aparna R SarasamSundararajan V Madihally

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