Effect of eldecalcitol on muscle function and fall prevention in Japanese postmenopausal women: A randomized controlled trial.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
Takeshi SaitoEiji Itoi

Abstract

Exercises and vitamin D interventions have shown to improve muscle function and balance, and prevent falls in postmenopausal healthy women and in patients with osteoporosis. However, the effects of eldecalcitol on these factors remain undetermined. The present open-label, randomized, controlled study aimed to investigate the effects of eldecalcitol treatment in reducing falls in postmenopausal women, and improving muscle function and balance. The study population included 226 Japanese postmenopausal women with osteoporosis. Patients were randomly divided into two groups on the basis of treatment with or without eldecalcitol (0.75 μg/day). Treatment continued for 6 months. Participants in both groups were instructed to perform back extensor muscle exercise. Isometric back extensor and leg extensor strength, grip power, ten-meter walking speed, timed up and go test and time of single leg standing were measured at baseline and 24 weeks. Patients were asked to record the number of falls during the 24-week period. The percentage increase in average bilateral quadriceps muscle strength was significantly higher in the eldecalcitol group compared with the non-eldecalcitol group (right, p = 0.041; left, p = 0.042). In contrast, there we...Continue Reading

References

Sep 1, 1996·Age and Ageing·D M BuchnerB J de Lateur
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heike A BischoffMartin Conzelmann
Apr 29, 2004·JAMA : the Journal of the American Medical Association·Heike A Bischoff-FerrariJohn B Wong
Jul 17, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M PfeiferH Dobnig
Dec 20, 2008·Journal of the American Geriatrics Society·Catherine SherringtonJacqueline C T Close
Aug 20, 2009·Journal of Bone and Mineral Metabolism·Yuji KasukawaYoichi Shimada
Oct 1, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul GlendenningRichard L Prince
Dec 14, 2011·The Journal of Nutrition, Health & Aging·O BeauchetC Annweiler
Dec 23, 2011·Journal of the American Geriatrics Society·Susan W Muir, Manuel Montero-Odasso
Jan 12, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W KemmlerS von Stengel
Apr 5, 2013·Journal of Bone and Mineral Metabolism·Satoshi SoenUNKNOWN Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the Revision of the
Mar 24, 2015·JAMA Internal Medicine·Kirsti Uusi-RasiHarri Sievänen
May 7, 2015·Journal of Bone and Mineral Metabolism·Hayato KinoshitaYoichi Shimada
Oct 7, 2016·British Journal of Sports Medicine·Catherine SherringtonStephen R Lord
Dec 27, 2016·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideo SaitoEiji Itoi
Aug 9, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N MiyakoshiY Shimada

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Citations

Jul 12, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hidetatsu TanakaMasamizu Oyama
Aug 24, 2021·Journal of Bone and Mineral Metabolism·Yu Mori, Toshimi Aizawa

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