Effect of electrical polarization of hydroxyapatite ceramics on new bone formation

Calcified Tissue International
S ItohS Itoh

Abstract

Large surface charges can be induced on hydroxyapatite (HAp) ceramics by proton transport polarization, but this does not affect beta-tricalcium phosphate (TCP) because of its low polarizability. We wished to examine differences in osteogenic cell activity and new bone growth between positively or negatively surface-charged HAp and HAp/TCP plates using a calvarial bone defect model. In the first group of rats, test pieces were placed with their positively charged surfaces face down on the dura mater. In the second group, test pieces were placed with their negatively charged surfaces face down on the dura mater. A third group received noncharged test pieces. Histological examination, including enzymatic staining for osteoblasts and osteoclasts, was carried out. While no bone formation was observed at the pericranium, direct bone formation on the cranial bone debris and new bone growth expanded from the margins of the sites of injury to bridge across both the positively and negatively charged surfaces of HAp and HAp/TCP plates occurred. Electrical polarization of implanted plates, including positive charge, led to enhanced osteoblast activity, though decreased osteoclast activity was seen on the positively charged plate surface. ...Continue Reading

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Citations

Aug 16, 2008·Journal of Materials Science. Materials in Medicine·Satoshi NakamuraKimihiro Yamashita
Dec 18, 2008·Journal of Materials Science. Materials in Medicine·R V SuganthiS Narayana Kalkura
Jun 26, 2013·Biomaterials·Greeshma ThrivikramanBikramjit Basu
Oct 22, 2013·The Journal of Veterinary Medical Science·Rumi HirataiKimihiro Yamashita
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Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ashutosh Kumar Dubey, Ken-ichi Kakimoto
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Feb 13, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Rumi OkabayashiKimihiro Yamashita
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Apr 3, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kohei NoharaKimihiro Yamashita
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Oct 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianyi ZhengXiaoping Yang

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