Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats

Acta Physiologica
Ella StoneT A Lovick

Abstract

To understand how deep brain stimulation of the midbrain influences control of the urinary bladder. In urethane-anaesthetized male rats, saline was infused continuously into the bladder to evoke cycles of filling and voiding. The effect of electrical (0.1-2.0 ms pulses, 5-180 Hz, 0.5-2.5 V) compared to chemical stimulation (microinjection of D,L-homocysteic acid, 50 nL 0.1 M solution) at the same midbrain sites was tested. Electrical stimulation of the periaqueductal grey matter and surrounding midbrain disrupted normal coordinated voiding activity in detrusor and sphincters muscles and suppressed urine output. The effect occurred within seconds was reversible and not secondary to cardiorespiratory changes. Bladder compliance remained unchanged. Chemical stimulation over the same area using microinjection of D,L-homocysteic acid (DLH) to preferentially activate somatodendritic receptors decreased the frequency of micturition but did not disrupt the coordinated pattern of voiding. In contrast, chemical stimulation within the caudal ventrolateral periaqueductal grey, in the area where critical synapses in the micturition reflex pathway are located, increased the frequency of micturition. Electrical deep brain stimulation within t...Continue Reading

References

May 1, 1987·Journal of the Autonomic Nervous System·C P Yardley, S M Hilton
Dec 1, 1982·Canadian Journal of Physiology and Pharmacology·P Gauthier, T A Reader
Sep 1, 1995·Acta Physiologica Scandinavica·M H KhadraC W Vaughan
Feb 22, 2002·Neurourology and Urodynamics·Paul AbramsUNKNOWN Standardisation Sub-committee of the International Continence Society
Oct 1, 1964·British Journal of Pharmacology and Chemotherapy·J M CRAWFORD, D R CURTIS
Jun 17, 2006·Annual Review of Neuroscience·Joel S Perlmutter, Jonathan W Mink
Jul 20, 2007·Nature Reviews. Neuroscience·Morten L KringelbachTipu Z Aziz
Dec 25, 2007·Nature Medicine·Lane BekarMaiken Nedergaard
Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Merrill J Birdno, Warren M Grill
Apr 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Atsushi NumataHidehiro Kakizaki
May 21, 2008·Nature Reviews. Neuroscience·Clare J FowlerWilliam C de Groat
Dec 22, 2009·Neurourology and Urodynamics·M J DrakeL Birder
Dec 22, 2009·Neurourology and Urodynamics·Gert Holstege
Nov 3, 2010·The European Journal of Neuroscience·Jean-Michel DeniauNicolas Maurice
Apr 14, 2011·The Journal of Physiology·E StoneT A Lovick
May 3, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Thomas J FeuersteinAndreas Moser
Jun 1, 2011·Molecular Psychiatry·V Vedam-MaiE M Hol
Jul 8, 2011·Frontiers in Systems Neuroscience·Charles J WilsonTheoden Netoff
Jul 26, 2012·Annals of Neurology·Alexander L GreenThelma A Lovick
Sep 13, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·P D CheneyG M Van Acker
Oct 5, 2012·Acta Physiologica·W C de Groat, C Wickens
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Satomi Chiken, Atsushi Nambu
Sep 7, 2013·The Journal of Pharmacology and Experimental Therapeutics·Prajni SadanandaAnthony E Pickering
Jan 25, 2014·CNS Neuroscience & Therapeutics·Albert J FenoyYing Xia
Mar 29, 2014·Frontiers in Systems Neuroscience·Satomi Chiken, Atsushi Nambu

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Citations

Apr 12, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Takeya KittaNobuo Shinohara
Aug 30, 2016·Autonomic Neuroscience : Basic & Clinical·J H Coote, R A Chauhan
Sep 25, 2019·Brain Sciences·Sarah Marie FarrellTipu Aziz
Oct 4, 2017·Frontiers in Physiology·Jonathan J Crook, Thelma A Lovick
Feb 21, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Charly B J BrouillardThelma A Lovick
Jun 6, 2018·Frontiers in Cellular Neuroscience·Céline MeriauxGommert A van Koeveringe
Mar 27, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Aryo ZareGommert A van Koeveringe
May 29, 2018·Molecular Neurobiology·Aryo ZareGommert A van Koeveringe
Dec 20, 2018·Lower Urinary Tract Symptoms·Jonathan ShawVivian Sung
Jun 4, 2021·ACS Applied Materials & Interfaces·Min-Ah OhTaek Dong Chung

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