PMID: 29071911Jun 25, 2016Paper

Effect of Electroacupuncture plus Polysaccharide of Gastrodia elata Blume on Expression of Nestin and Brain Derived Neurotrophic Factor in the Basolateral Amygdala of Focal Cerebral Ischemia Rats

Zhen ci yan jiu = Acupuncture research
Rui HuangKe-Ren Xiong

Abstract

To observe the effect of electroacupuncture (EA) combined with administration of Polysaccharide of Gastrodia elata Blume (PGB) on stem cell proliferation in the basolateral amygdala (BLA) of focal cerebral ischemia (FCI) rats. A total of 40 Sprague-Dawley rats were randomly divided into normal control,model,EA, PGB and EA+PGB groups (n=8 rats in each group). The FCI model was established by occlusion of the right middle cerebral artery. EA (2 Hz, 3 V) was applied to "Baihui" (GV 20) and the left "Zusanli"(ST 36) for 30 min, once daily for 14 successive days. Rats of the PGB and EA+PGB groups were given with PGB (100 mg/kg) by gastrogavage, once daily, for14 successive days. The Zea-Longa's method was used to determine the animals' nerurological dysfunction score on day 1 and 14. The expressions of Nestin and brain derived neurotrophic factor (BDNF) of the right BLA were measured by immunohistochemical staining. Following modeling, the neurological score, and the numbers of Nestin- and BDNF-immunoreaction (IR)-positive cells were significantly increased in the model group (P<0.05). Compared with the model group, the neurological scores were considerably decreased in the EA, PGB and EA+PGB groups (P<0.05), and the numbers of Nest...Continue Reading

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