Effect of elevated circulating progesterone concentration on bovine blastocyst development and global transcriptome following endoscopic transfer of in vitro produced embryos to the bovine oviduct

Biology of Reproduction
F CarterP Lonergan

Abstract

Elevated concentrations of circulating progesterone in the immediate postconception period have been associated with an increase in embryonic growth rate, interferon-tau production, and pregnancy rate in cattle and sheep. Much of this effect is likely mediated via downstream effects of progesterone-induced changes in gene expression in the uterine tissues. Using state-of-the-art endoscopic techniques, this study examined the effect of elevated progesterone on the development of in vitro produced bovine zygotes transferred to the oviducts of heifers with high or normal circulating progesterone concentrations and on the transcriptome of blastocysts developing under such conditions. Simmental heifers (n = 34) were synchronized using a controlled internal drug release (CIDR) device for 8 days, with a prostaglandin F(2 alpha) analogue administered 3 days before removal of the CIDR device. Only animals exhibiting a clear standing estrus (Day 0) were used. To produce animals with divergent progesterone concentrations, half of the animals received a progesterone-releasing intravaginal device (PRID) on Day 3 of the estrous cycle; the PRID was left in place until embryo recovery. All animals were sampled for blood daily from Day 0 to Day...Continue Reading

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Citations

Jan 30, 2013·In Vitro Cellular & Developmental Biology. Animal·Ana TorresLuís Lopes-da-Costa
Dec 7, 2013·Reproduction, Fertility, and Development·M HoelkerD Tesfaye
Apr 8, 2014·Animal : an International Journal of Animal Bioscience·M C WiltbankM G Diskin
Nov 19, 2013·Tropical Animal Health and Production·Thaisa Campos MarquesRoberto Sartori
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Aug 25, 2012·Animal Reproduction Science·A GadD Tesfaye
Feb 19, 2017·The Journal of Endocrinology·Kazuhiko ImakawaKazuya Kusama
Sep 10, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·N Forde, P Lonergan
Jun 9, 2018·Asian-Australasian Journal of Animal Sciences·Guoli ZhaoYuangang Shi
Apr 9, 2014·Reproduction, Fertility, and Development·B TrigalE Gómez
May 1, 2015·Biology of Reproduction·Veronica MailloDimitrios Rizos
Feb 1, 2015·Reproduction, Fertility, and Development·Pat LonerganThomas Spencer
Jul 28, 2018·Journal of Animal Science·Thaise P MeloRoberto Carvalheiro
Sep 11, 2019·Animal Science Journal = Nihon Chikusan Gakkaihō·Alan Willmore, Tracy L Davis
Feb 7, 2020·Animal : an International Journal of Animal Bioscience·U BesenfelderV Havlicek
Jul 6, 2020·Journal of Dairy Science·P Lonergan, J M Sánchez
Nov 20, 2016·Annals of the New York Academy of Sciences·Elissa Z CameronLaura M Parsley
Mar 28, 2020·Journal of Assisted Reproduction and Genetics·Irene ZolfaroliAntonio Cano
Jan 1, 2018·Reproduction, Fertility, and Development·P LonerganTrudee Fair
Jan 25, 2020·Theriogenology·Beatriz Rodríguez-AlonsoDimitrios Rizos

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Methods Mentioned

BETA
in vitro transcription
chip
PCR
electrophoresis

Software Mentioned

EASE ( Expression Analysis Systematic Explorer )
DAVID
Ingenuity Pathway Analysis
Affymetrix
GCOS
GeneSpring
Primer Express

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