Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Shivsharan B DhaddeS Badami

Abstract

3-Nitropropionic acid (3-NP) causes severe neurotoxicity in animals, which depicts Huntington's disease (HD) in humans. Embelin, the main active constituent of Embelia ribes, has been reported to possess various pharmacological actions, mainly anti-inflammatory, antioxidant, anticonvulsant and neuroprotective. The aim of the present study was to evaluate the neuroprotective effect of embelin against 3-NP induced experimental HD in rats. Adult Wistar rats were pretreated with vehicle/embelin (10 and 20mg/kg p.o.) for 7 days. From 8th day onwards, embelin was co-treated with 3-NP (15mg/kg, i.p.) for 7 days. At the end of the treatment schedule, animals were evaluated for behavioral alterations and brain homogenates were used for estimation of oxidative stress parameters (lipid peroxidation, reduced glutathione, catalase and glutathione-S-transferase). 2,3,5-Triphenyl tetrazolium chloride (TTC) stained brain slices were used for lesion size measurement. Administration of 3-NP significantly altered the behavioral and neuronal antioxidant status and caused significant neuronal damage in striatal region. Embelin, at both the tested doses, caused a significant reversal of behavioral and antioxidant status alterations and reversed the ...Continue Reading

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Citations

Apr 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sharanbasappa DurgShrishailappa Badami
Jun 28, 2017·Redox Report : Communications in Free Radical Research·K Parasram
Nov 16, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Noha H SayedAhmed S Kamel
Feb 19, 2016·Phytotherapy Research : PTR·Ashique ShaikhJagadevappa S Patil
Mar 16, 2017·Frontiers in Pharmacology·Uday P KundapMohd Farooq Shaikh
Jan 29, 2020·Biochimica Et Biophysica Acta. Bioenergetics·Swetha Pavani RaoShasi V Kalivendi
Aug 16, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edward J CalabreseRehana K Leak
Jun 2, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Priya SharmaNitin Bansal
Jun 5, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Muhammed A SaadNoha F Abdelkader
Jun 25, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Subramanyam PolopalliPhani Kumar Kola
May 1, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Melissa Talita WiprichCarla Denise Bonan
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ravi Chandra Sekhara Reddy DandugaVijaya Kishore Kanakaraju

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