Abstract
3-Nitropropionic acid (3-NP) causes severe neurotoxicity in animals, which depicts Huntington's disease (HD) in humans. Embelin, the main active constituent of Embelia ribes, has been reported to possess various pharmacological actions, mainly anti-inflammatory, antioxidant, anticonvulsant and neuroprotective. The aim of the present study was to evaluate the neuroprotective effect of embelin against 3-NP induced experimental HD in rats. Adult Wistar rats were pretreated with vehicle/embelin (10 and 20mg/kg p.o.) for 7 days. From 8th day onwards, embelin was co-treated with 3-NP (15mg/kg, i.p.) for 7 days. At the end of the treatment schedule, animals were evaluated for behavioral alterations and brain homogenates were used for estimation of oxidative stress parameters (lipid peroxidation, reduced glutathione, catalase and glutathione-S-transferase). 2,3,5-Triphenyl tetrazolium chloride (TTC) stained brain slices were used for lesion size measurement. Administration of 3-NP significantly altered the behavioral and neuronal antioxidant status and caused significant neuronal damage in striatal region. Embelin, at both the tested doses, caused a significant reversal of behavioral and antioxidant status alterations and reversed the ...Continue Reading
References
Sep 14, 1990·Biochimica Et Biophysica Acta·D Gelvan, P Saltman
Nov 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH M Bartkowski
Mar 1, 1994·Chemotherapy·M ChitraC S Devi
May 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B G JenkinsB R Rosen
Apr 1, 1996·Neuroscience·J B SchulzM F Beal
Jul 1, 1997·Neuroscience·M C GuyotE Brouillet
Dec 22, 1999·Methods and Findings in Experimental and Clinical Pharmacology·C S Patil, S K Kulkarni
Mar 4, 2000·Neuropharmacology·A J HunterA A Parsons
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Julie Leegwater-Kim, Jang-Ho J Cha
Feb 23, 2005·Current Drug Targets. CNS and Neurological Disorders·James W SimpkinsJames A Dykens
Sep 6, 2005·Brain Research Bulletin·Mohammad TariqKhalaf Al Moutaery
Mar 15, 2006·Neuroscience·Y-N SongJ-J Wang
Jan 11, 2007·Behavioural Brain Research·Xue-Bo YanJiang-Ning Zhou
Mar 24, 2007·Chemico-biological Interactions·Ravi JoshiTulsi Mukherjee
Sep 27, 2007·CNS Drug Reviews·Yasushi ItoHideaki Hara
Jan 1, 2008·Toxicology·Manuj AhujaKanwaljit Chopra
Apr 16, 2009·Neuroscience Research·Puneet Kumar, Anil Kumar
Oct 14, 2009·Life Sciences·Puneet KumarAnil Kumar
Oct 1, 2008·Indian Journal of Pharmacology·Uma Bhandari, M Nazam Ansari
Jan 28, 2010·Basic & Clinical Pharmacology & Toxicology·Puneet KumarAnil Kumar
Jul 8, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S MahendranS Badami
Jul 14, 2011·Neurotoxicity Research·B S ThippeswamyS Badami
Jan 24, 2013·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Pandian NagakannanV P Veerapur
Apr 18, 2013·Drug and Chemical Toxicology·B D ShivasharanMazhuvancherry K Unnikrishnan
Jan 16, 2014·Indian Journal of Clinical Biochemistry : IJCB·B D ShivasharanV P Veerapur
Citations
Oct 17, 2016·Molecular Neurobiology·Rimpi Arora, Rahul Deshmukh
Apr 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sharanbasappa DurgShrishailappa Badami
Jun 28, 2017·Redox Report : Communications in Free Radical Research·K Parasram
Nov 9, 2019·Natural Product Research·K P Rini Vijayan, A V Raghu
Nov 16, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Noha H SayedAhmed S Kamel
Feb 19, 2016·Phytotherapy Research : PTR·Ashique ShaikhJagadevappa S Patil
Apr 24, 2018·Neurological Research·Bailing WangXiaoying Wang
Feb 26, 2020·Nutritional Neuroscience·Mohd SalmanSuhel Parvez
Mar 16, 2017·Frontiers in Pharmacology·Uday P KundapMohd Farooq Shaikh
Aug 19, 2018·Neurochemical Research·Peng LiuLibo Zou
Jul 25, 2019·Neurotoxicity Research·Mohamed S AbdelfattahRami B Kassab
Dec 5, 2018·Molecular Biology Reports·Dirleise ColleMarcelo Farina
Nov 10, 2020·Nutritional Neuroscience·Jai MalikSunayna Choudhary
Jan 8, 2021·Nanomedicine·Amanda CanoAntonio Camins
Jan 22, 2021·ACS Chemical Neuroscience·Pei Teng LumMohd Farooq Shaikh
Feb 14, 2021·Translational Psychiatry·O DamriG Agam
Nov 21, 2020·Acta Pharmacologica Sinica·Xiong YangNai-Hong Chen
Jan 25, 2020·Bioorganic Chemistry·Antony StalinPerumal Palani
Jan 29, 2020·Biochimica Et Biophysica Acta. Bioenergetics·Swetha Pavani RaoShasi V Kalivendi
Aug 16, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edward J CalabreseRehana K Leak
Jul 14, 2020·Life Sciences·Ayman E El-SaharMuhammed A Saad
Apr 16, 2021·Nutritional Neuroscience·Mohd SalmanSuhel Parvez
Jun 2, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Priya SharmaNitin Bansal
Jun 5, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Muhammed A SaadNoha F Abdelkader
Jun 25, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Subramanyam PolopalliPhani Kumar Kola
May 1, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Melissa Talita WiprichCarla Denise Bonan
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ravi Chandra Sekhara Reddy DandugaVijaya Kishore Kanakaraju