Effect of endocrine disruptor phytoestrogens on the immune system: Present and future

Acta Microbiologica Et Immunologica Hungarica
Gyorgy Csaba

Abstract

Endocrine disruptors (EDs) are bound by steroid receptors, have steroid-like effects, and by this, negatively influence hormone-regulated processes. Phytoestrogens, which are consumed in enormously high amount by man, are also EDs; however, in contrast to industrial or communal EDs, in some cases have beneficial effects. As immune cells have steroid (first of all, estrogen) nuclear and plasma membrane receptors, which bind phytostrogens (genistein, daidzein, etc.), the development, lifespan, and function of them are deeply influenced by phytoestrogens. They can provoke perinatal faulty hormonal imprinting with lifelong consequences. However, faulty imprinting can be developed not only perinatally but also in other critical periods of life, as weaning, adolescence, and even in continuously dividing cells (e.g., hemopoietic cells) during the whole life. This means that the phytoestrogens could cause direct - instant or long-lasting - steroid effects and durable imprinting effects. As the effect of hormonal imprinting is epigenetically inherited, the phytoestrogen's effects appear in the progeny generations, and the generationally repeated disruptor effects will be different from the present ones. This could also be manifested in ...Continue Reading

Citations

Jul 18, 2018·Acta Microbiologica Et Immunologica Hungarica·György Csaba
Aug 12, 2020·Phytotherapy Research : PTR·Jéssica C P Petrine, Bruno Del Bianco-Borges
Jul 4, 2018·Acta Microbiologica Et Immunologica Hungarica·György Csaba
Mar 12, 2021·Environmental Pollution·Wisurumuni Arachchilage Hasitha Maduranga KarunarathneGi-Young Kim

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