Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle

The Journal of Physiology
L ShaJ H Szurszewski

Abstract

A transwall gradient in resting membrane potential (RMP) exists across the circular muscle layer in the mouse colon. This gradient is dependent on endogenous generation of CO. H2S is also generated in muscle layers of the mouse colon. The effect of endogenously generated H2S on the transwall gradient is not known. The aim was to investigate the role of endogenous H2S. Our results showed that the CSE inhibitor dl-propargylglycine (PAG, 500 μm) had no effect on the transwall gradient. However, in preparations pretreated with the nitric oxide synthase inhibitor N-nitro-l-arginine (l-NNA, 200 μm) and in nNOS-knockout (KO) mouse preparations, PAG shifted the transwall gradient in the depolarizing direction. In CSE-KO-nNOS-KO mice, the gradient was shifted in the depolarizing direction. Endogenous generation of NO was significantly higher in muscle preparations of CSE-KO mice compared to wild-type (WT) mice. The amplitude of NO-mediated slow inhibitory junction potentials (S-IJPs) evoked by electric field stimulation was significantly higher in CSE-KO mouse preparations compared to the amplitude of S-IJPs in wild-type mouse preparations. CSE was present in all submucosal ganglion neurons and in almost all myenteric ganglion neurons. ...Continue Reading

References

Oct 1, 1987·Gastrointestinal Endoscopy·D FranceschiP F Chen
Mar 1, 1986·The Journal of Physiology·Y HaraJ H Szurszewski
Mar 1, 1987·The American Journal of Physiology·T K SmithK M Sanders
Sep 1, 1985·The Journal of Physiology·A J BauerK M Sanders
Feb 1, 1993·Gastroenterology·M E StarkJ H Szurszewski
Jul 1, 1996·The Journal of Clinical Investigation·H MashimoR K Goyal
Aug 28, 1997·Biochemical and Biophysical Research Communications·R HosokiH Kimura
Oct 6, 2001·Nitric Oxide : Biology and Chemistry·H SutherlandS Salmons
Nov 16, 2002·The Journal of Biological Chemistry·Jinling WangPaul R Ortiz de Montellano
Feb 1, 2003·European Journal of Pharmacology·Rosa SerioFlavia Mulè
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gianrico FarrugiaJoseph H Szurszewski
Jul 26, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrei SibaevMartin Storr
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J H Szurszewski, G Farrugia
May 19, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lei ShaJoseph H Szurszewski
Jun 3, 2008·Journal of Neurochemistry·David R LindenJoseph H Szurszewski
Jul 5, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Diana GallegoMarcel Jiménez
Oct 7, 2009·Antioxidants & Redox Signaling·Hideo Kimura
Nov 27, 2009·Antioxidants & Redox Signaling·Mayumi KajimuraMakoto Suematsu
Nov 27, 2009·Cardiology·Guang-Zhen ZhongXin-Chun Yang
Jun 15, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L ShaJ H Szurszewski
Jul 20, 2010·Clinical and Experimental Pharmacology & Physiology·Guanghua TangRui Wang
Oct 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna V KalinchukRadhika Basheer
Feb 9, 2011·Current Opinion in Nephrology and Hypertension·Rui Wang
Oct 8, 2011·Circulation Research·Asif K MustafaSolomon H Snyder
Mar 1, 2012·The Journal of Physiology·Diana GallegoMarcel Jiménez
Jan 10, 2013·British Journal of Pharmacology·V GilM Jimenez
Mar 12, 2013·Postȩpy higieny i medycyny doświadczalnej·Marcin MagierowskiTomasz Brzozowski

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Citations

Oct 11, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hideo Kimura
May 7, 2014·Gastroenterology·Gianrico Farrugia, Joseph H Szurszewski
Feb 3, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M Martinez-CutillasM Jimenez
May 8, 2014·Antioxidants & Redox Signaling·Hideo Kimura
Jan 11, 2017·Antioxidants & Redox Signaling·Gopi K KolluruChristopher G Kevil
Jul 15, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ancy D NalliKarnam S Murthy
Oct 4, 2017·Pharmacology Research & Perspectives·Ancy D NalliKarnam S Murthy
Sep 20, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Xiaomeng XuChuanyong Liu
Jan 9, 2015·American Journal of Physiology. Cell Physiology·Ancy D NalliKarnam S Murthy
Dec 25, 2019·Nitric Oxide : Biology and Chemistry·Taiming LiuArlin B Blood

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