Effect of endomorphin-2 on orofacial pain induced by orthodontic tooth movement in rats

European Journal of Oral Sciences
Sixin LiuWenli Lai

Abstract

Endomorphin-2 demonstrates potent antinociceptive effects in various pain models. The objectives of the present study were to explore the role of endomorphin-2 in the modulation of orofacial pain induced by orthodontic tooth movement in rats. An orthodontic pain model was established in male Sprague-Dawley rats by ligating coiled springs to mimic orthodontic force (40 g). On days 0, 1, 3, 5, 7, and 14 following orthodontic tooth movement, bite force was recorded as a surrogate measure of orthodontic pain. Ipsilateral trigeminal ganglia, trigeminal nucleus caudalis, and periodontal tissues were harvested for immunostaining. Endomorphin-2, endomorphin-2 + naloxone (a non-selective opioid receptor antagonist), naloxone, and saline were injected into trigeminal ganglia and periodontal tissues to explore the role of endomorphin-2 on orthodontic pain. The results showed that following orthodontic tooth movement, endomorphin-2 expression levels in trigeminal ganglia were elevated on days 1, 3, 5, and 7. Orthodontic pain levels were increased on days 1, 3, and 5. The administration of endomorphin-2 into both trigeminal ganglia and periodontal tissues alleviated orthodontic pain. Moreover, the effects of endomorphin-2 could be blocked b...Continue Reading

References

Oct 1, 1991·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·D F Brown, R G Moerenhout
May 26, 1986·Life Sciences·G W Pasternak, P J Wood
Oct 1, 1985·British Journal of Orthodontics·R G Oliver, Y M Knapman
Jan 1, 1983·Annual Review of Neuroscience·R Dubner, G J Bennett
Feb 1, 1993·Clinical Neuropharmacology·G W Pasternak
Aug 7, 1993·Lancet·C SteinA Yassouridis
Apr 8, 1996·The Journal of Comparative Neurology·Y Q DingN Mizuno
Jan 8, 1999·Peptides·S Martin-SchildJ E Zadina
Mar 31, 1999·The Journal of Comparative Neurology·S Martin-SchildJ E Zadina
Feb 17, 2000·Annals of the New York Academy of Sciences·J E ZadinaX Zhang
Mar 18, 2000·Journal of Chemical Neuroanatomy·F J Rodríguez-GómezJ A Muñoz-Cueto
Aug 20, 2002·Japanese Journal of Pharmacology·Leon F Tseng
Nov 2, 2002·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·G Thomas KluemperMichael J Jay
Apr 15, 2004·Neuroscience Letters·Ilona ObaraBarbara Przewlocka
Sep 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haibin WangClifford J Woolf
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dominika LabuzHalina Machelska
Mar 3, 2007·Pharmacological Reviews·Jakub FichnaJean-Claude Do Rego
May 10, 2007·European Journal of Orthodontics·Vinod Krishnan
Oct 18, 2008·Neuroscience Letters·Junad KhanEli Eliav
Jul 25, 2009·European Journal of Oral Sciences·Zhi YangZhenyu Liao
Sep 4, 2009·Current Treatment Options in Oncology·Stuart M Lichtman
Nov 12, 2010·Nature Reviews. Neuroscience·Andrew J Todd
Apr 5, 2012·Mediators of Inflammation·Paola Sacerdote, Luca Levrini
Apr 16, 2013·The Angle Orthodontist·Hu LongWenli Lai
May 9, 2013·The Angle Orthodontist·Lina LiaoWenli Lai
Dec 12, 2013·Progress in Orthodontics·Ghada NimeriRachel Corona
Jan 17, 2014·European Journal of Oral Sciences·Lina LiaoWenli Lai
Jan 10, 2017·European Journal of Oral Sciences·Hu LongWenli Lai
Dec 21, 2017·Anesthesia and Analgesia·Ana BaguesEva María Sánchez-Robles
Mar 29, 2018·Journal of Pain Research·Francielle TopolskiSasha Cristina Schimim

❮ Previous
Next ❯

Citations

Aug 9, 2020·Orthodontics & Craniofacial Research·Cui-Xia LiZe-Xu Gu
May 22, 2021·Frontiers in Neuroscience·Qing LiuFang Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.