PMID: 9536957Apr 16, 1998Paper

Effect of endoscopic sphincterotomy on gall bladder bile lithogenicity and motility

Gut
B C SharmaV A Saraswat

Abstract

Endoscopic sphincterotomy has been shown to inhibit stone formation in the gall bladder of experimental animals. To investigate the alterations in bile composition and gall bladder motility after endoscopic sphincterotomy. A study was performed of gall bladder bile composition and gall bladder motility in patients with gallstone disease ((n = 20; age 40-60 years, median age 55 years: seven men), with gall bladder calculi (n = 12) and with diseased gall bladder (chronic inflammation) without gall bladder calculi (n = 8)), who had received endoscopic sphincterotomy for common bile duct stones. Age and sex matched disease controls comprised 20 patients with gallstone disease but without stones and an intact sphincter of Oddi (with gall bladder calculi (n = 10) and diseased gall bladder without gall bladder calculi (n = 10)). Gall bladder motility was assessed by ultrasound. Duodenal bile collected by nasoduodenal tube after stimulation of gall bladder by intravenous ceruletid infusion was analysed for cholesterol, phospholipid, and bile acid concentrations, cholesterol saturation index, and nucleation time. There was a significant reduction in mean (SEM) fasting volume (12.5 (1.7) ml v 26.4 (2.5) ml; p < 0.001) and mean (SEM) resi...Continue Reading

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Citations

Feb 23, 1999·The Medical Journal of Australia·C H Wriedt
Dec 10, 1999·The New England Journal of Medicine·W R Brugge, J Van Dam
Oct 7, 2006·Current Opinion in Gastroenterology·W A Hoogerwerf, R D Soloway
Apr 30, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-K LiuJ-H Dong
Feb 22, 2002·The Korean Journal of Internal Medicine·S K KwonS M Park
Aug 15, 2003·World Journal of Gastroenterology : WJG·Ming-Guo TianDong-Feng Zhou
Oct 9, 2009·Scandinavian Journal of Gastroenterology·Kjell-Arne UngAntal Bajor
Nov 30, 2000·Current Treatment Options in Gastroenterology·T A Broughan
Oct 16, 1999·Annals of Internal Medicine·T H Baron

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