PMID: 7541100Jan 1, 1995Paper

Effect of endothelin-1 on arterial response to Bay K 8644. A comparison of ischemic and nonischemic arteries

Life Sciences
J D EdwardsD K Agrawal

Abstract

Endothelin-1 (ET-1) has been proposed as one of the possible mediators of the vasoconstriction seen following ischemia and reperfusion. We investigated the effect of ischemia and reperfusion on the contractile response of canine renal and iliac arteries to the dihydropyridine-type calcium channel agonist (+/-)Bay K 8644, following subthreshold doses of ET-1. No significant difference in the maximum tension was observed between the ischemic and nonischemic arteries in response to Bay K 8644 in the absence of ET-1. The addition of subthreshold dose of ET-1 (10(-10) M) resulted in a significant increase in sensitivity to Bay K 8644 in both the ischemic-reperfused and non-ischemic-reperfused arteries, with a 38 fold increase in iliac arteries and about 8 fold increase in the renal arteries. However, the ET-1 potentiated response was enhanced in the ischemic-reperfused in comparison to the non-ischemic-reperfused vessels in the iliac artery. These data suggest that the potentiating mechanism of ET-1 is not only intact, but enhanced in ischemic-reperfused vessels. Since the enhanced release of ET-1 in vivo is preceded by ischemia and reperfusion, the vasospastic phenomenon observed following these events could well be mediated by ET-1.

References

Jan 1, 1991·Journal of Cardiovascular Pharmacology·K NakayamaY Tanaka
May 1, 1987·Journal of Cardiovascular Pharmacology·D K AgrawalJ H McNeill
Oct 14, 1988·Biochemical and Biophysical Research Communications·M AuguetP Braquet
Dec 30, 1988·Biochemical and Biophysical Research Communications·C Van RenterghemM Lazdunski
Jan 1, 1989·Journal of Cardiovascular Pharmacology·T GodfraindM Wibo
Jan 1, 1989·Journal of Cardiovascular Pharmacology·P M VanhoutteM Vidal
Jan 16, 1989·Biochemical and Biophysical Research Communications·P A MarsdenT A Brock
Mar 31, 1989·Biochemical and Biophysical Research Communications·Y TabuchiT Ogihara
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K GotoT Masaki
Dec 30, 1988·Biochemical and Biophysical Research Communications·T J ResinkF R Bühler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.