Effect of endothelin-1 on the development of hemorrhagic pancreatitis in rats

Scandinavian Journal of Gastroenterology
X H LiuH Nawata

Abstract

It has been hypothesized that microcirculatory disturbance plays an important role in the development of severe pancreatitis. In this study we investigated the effects of exogenous endothelin-1 on the development of severe pancreatitis in rats. Acute pancreatitis was induced by two intraperitoneal injections of cerulein (10 micrograms/kg body weight). Endothelin-1 was administered via an abdominal aortic catheter as a bolus of 250-750 pmol/kg BW every hour for 4 h. Remarkable morphologic changes in the pancreas, including hemorrhage, and increases in serum amylase level and active elastase content in pancreatic tissue were observed in rats treated with cerulein plus endothelin-1 in a dose-dependent manner 5 h after the first cerulein injection. Local pancreatic blood flow decreased significantly, and microcirculatory disturbances in the pancreas were demonstrated. These results suggest that endothelin-1 causes pancreatic microcirculatory disturbance and might be a contributing factor in the aggravation of acute pancreatitis.

References

Apr 1, 1992·Alcoholism, Clinical and Experimental Research·S TsujiT Kamada
Jan 1, 1992·Life Sciences·K TakaoriT Tobe
Jun 1, 1990·Gastroenterology·H YamaguchiH Nawata
Dec 1, 1990·The Journal of Experimental Medicine·H EhrenreichA S Fauci
Jan 31, 1991·Biochemical and Biophysical Research Communications·W C SessaJ R Vane
Jul 1, 1991·The Journal of Clinical Investigation·T E Bunchman, C A Brookshire
Jun 1, 1990·The American Journal of Medicine·M KohnoT Takeda
Jan 15, 1990·Biochemical and Biophysical Research Communications·M YoshizumiY Yazaki
Jan 1, 1989·Pancreas·H YamaguchiH Nawata
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A InoueT Masaki
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M W MacCumberS H Snyder
Jan 1, 1985·Annual Review of Medicine·A Janoff
Dec 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·M CeskaB Brown
Dec 1, 1970·American Journal of Surgery·P S BinderJ J Bergan
Feb 1, 1964·Circulation Research·K AUKLANDR W BERLINER

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Citations

Oct 1, 1995·Digestive Diseases and Sciences·X LiuH Nawata
Jun 24, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Brigitte Vollmar, Michael D Menger
Jan 22, 2008·World Journal of Gastroenterology : WJG·Ibrahim-A Al Mofleh
Apr 1, 1995·Journal of Gastroenterology·X H LiuH Nawata
Mar 23, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Anna Andrzejewska, Jan W Dlugosz
Jul 1, 2008·Microvascular Research·Dirk UhlmannHelmut Witzigmann
Nov 19, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jan W DlugoszEugeniusz Wroblewski
Jul 29, 1999·The Journal of Surgical Research·T PlusczykG Feifel
Nov 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·M DoboszZ Wajda
Jun 12, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·T PlusczykM Schilling
Jun 5, 2002·World Journal of Gastroenterology : WJG·Zong-Guang Zhou, You-Dai Chen
Jun 12, 2013·Molecular Medicine Reports·Hiroyuki FurukawaShoichi Iseki
Jun 11, 1999·The American Journal of Physiology·E von DobschuetzK Messmer
Dec 11, 2014·World Journal of Gastroenterology : WJG·Jing LiCheng-Wei Tang
Mar 27, 2007·Gastroenterology·Stephen J PandolPeter A Banks

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