Abstract
To assess whether the association between reperfusion and improved clinical outcomes after stroke differs depending on the site of the arterial occlusive lesion (AOL). We pooled data from Solitaire With the Intention for Thrombectomy (SWIFT), Solitaire FR Thrombectomy for Acute Revascularisation (STAR), Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study 2 (DEFUSE 2), and Interventional Management of Stroke Trial (IMS III) to compare the strength of the associations between reperfusion and clinical outcomes in patients with internal carotid artery (ICA), proximal middle cerebral artery (MCA) (M1), and distal MCA (M2/3/4) occlusions. Among 710 included patients, the site of the AOL was the ICA in 161, the proximal MCA in 389, and the distal MCA in 160 patients (M2 = 131, M3 = 23, and M4 = 6). Reperfusion was associated with an increase in the rate of good functional outcome (modified Rankin Scale [mRS] score 0-2) in patients with ICA (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.7-7.2) and proximal MCA occlusions (OR 6.2, 95% CI 3.8-10.2), but not in patients with distal MCA occlusions (OR 1.4, 95% CI 0.8-2.6). Among patients with M2 occlusions, a subset of the distal MCA cohort, reperfusio...Continue Reading
References
Apr 1, 1995·Stroke; a Journal of Cerebral Circulation·R von KummerW Hacke
Jun 18, 2005·Stroke; a Journal of Cerebral Circulation·Wade S SmithUNKNOWN MERCI Trial Investigators
Jan 30, 2007·Lancet·Nils WahlgrenUNKNOWN SITS-MOST investigators
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Joung-Ho Rha, Jeffrey L Saver
Mar 14, 2008·AJNR. American Journal of Neuroradiology·T TomsickUNKNOWN Interventional Management of Stroke II Investigators
Jul 11, 2009·Stroke; a Journal of Cerebral Circulation·UNKNOWN Penumbra Pivotal Stroke Trial Investigators
Oct 31, 2009·Stroke; a Journal of Cerebral Circulation·Raul G NogueiraUNKNOWN Multi MERCI Writing Committee
Mar 29, 2011·Stroke; a Journal of Cerebral Circulation·Aymeric RouchaudPierre Amarenco
Mar 1, 2012·Stroke; a Journal of Cerebral Circulation·Aekaterini GalimanisJan Gralla
Aug 31, 2012·Lancet·Raul G NogueiraUNKNOWN TREVO 2 Trialists
Aug 31, 2012·Lancet·Jeffrey L SaverUNKNOWN SWIFT Trialists
Sep 8, 2012·Lancet Neurology·Maarten G LansbergUNKNOWN DEFUSE 2 study investigators
Dec 12, 2012·Stroke; a Journal of Cerebral Circulation·Ralph RahmePooja Khatri
Feb 9, 2013·The New England Journal of Medicine·Joseph P BroderickUNKNOWN Interventional Management of Stroke (IMS) III Investigators
Jul 16, 2013·Neurology·Robin LemmensMaarten G Lansberg
Aug 3, 2013·Stroke; a Journal of Cerebral Circulation·Vitor M PereiraGerhard Schroth
Dec 18, 2013·Stroke; a Journal of Cerebral Circulation·Michael D HillUNKNOWN IMS3 Investigators
Jan 1, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Robin LemmensMaarten G Lansberg
Mar 1, 2014·Journal of Neurointerventional Surgery·Alan FloresUNKNOWN Catalan Stroke Code and Reperfusion Consortium Cat-SCR
May 14, 2014·Journal of Neurointerventional Surgery·Sunil A ShethUNKNOWN UCLA Comprehensive Stroke Center
Citations
Dec 6, 2016·Scientific Reports·Sonu BhaskarChristopher Levi
Feb 17, 2017·Cerebrovascular Diseases·Verena van GinnekenJochen B Fiebach
Jan 13, 2017·A & a Case Reports·Anne M BaciewiczAlex T Lee
Jul 15, 2017·Journal of Neurointerventional Surgery·Hisham SalahuddinMouhammad Jumaa
Jun 20, 2018·Stroke; a Journal of Cerebral Circulation·Wolfgang G KunzMayank Goyal
Jan 26, 2018·Stroke; a Journal of Cerebral Circulation·William J PowersUNKNOWN American Heart Association Stroke Council
Nov 30, 2016·Stroke; a Journal of Cerebral Circulation·Maarten G LansbergPhilip W Lavori
Oct 20, 2018·Neuroradiology·Hyon-Jo KwonHyeon-Song Koh
May 1, 2019·Acta neurochirurgica·Yong-Won KimDong-Hun Kang
Jun 5, 2018·Journal of Neurosurgical Anesthesiology·Gabriela AlcarazLashmi Venkatraghavan
Nov 12, 2017·Journal of Neurointerventional Surgery·Hamidreza SaberSunil A Sheth
Oct 31, 2019·Stroke; a Journal of Cerebral Circulation·William J PowersDavid L Tirschwell
Nov 10, 2017·Interventional Neurology·Hisham SalahuddinMouhammad A Jumaa
Nov 10, 2017·Interventional Neurology·Niko SillanpääHarri Rusanen
May 7, 2019·Frontiers in Neurology·Xiaoxian GongMin Lou
Dec 17, 2020·Journal of Neurointerventional Surgery·Raul G NogueiraUNKNOWN Trevo Registry Investigators
Jan 27, 2021·Stroke; a Journal of Cerebral Circulation·Tomas DobrockyMirjam R Heldner
Feb 23, 2021·Journal of Magnetic Resonance Imaging : JMRI·Xinyu WangChao Zhang
Apr 18, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Seung Hwan KimSung-Chul Jin
May 12, 2021·World Neurosurgery·Mohammad AnadaniAlejandro M Spiotta
Mar 16, 2017·Stroke; a Journal of Cerebral Circulation·Mònica MillánUNKNOWN REVASCAT Trial Investigators
Aug 28, 2021·Journal of Personalized Medicine·Sang-Hwa LeeJong-Hee Sohn