Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats

Brain Research
Jana TchekalarovaKaterina N Georgieva

Abstract

The therapeutic efficacy of regular physical exercises in an animal model of epilepsy and depression comorbidity has been confirmed previously. In the present study, we examined the effects of endurance training on susceptibility to kainate (KA)-induced status epilepticus (SE), behavioral changes and neuronal damage in spontaneously hypertensive rats (SHRs). Male SHRs were randomly divided into two groups. One group was exercised on a treadmill with submaximal loading for four weeks and the other group was sedentary. Immediately after the training period, SE was evoked in half of the sedentary and trained rats by KA, while the other half of the two groups received saline. Basal systolic (SP), diastolic (DP) and mean arterial pressure (MAP) of all rats were measured at the beginning and at the end of the training period. Anxiety, memory and depression-like behaviour were evaluated a month after SE. The release of 5-HT in the hippocampus was measured using a liquid scintillation method and neuronal damage was analyzed by hematoxylin and eosin staining. SP and MAP of exercised SHRs decreased in comparison with the initial values. The increased resistance of SHRs to KA-induced SE was accompanied by an elongated latent seizure-free ...Continue Reading

References

May 1, 1992·Acta Physiologica Scandinavica·S P BaileyE N Ahlborn
Sep 1, 1989·Acta Physiologica Scandinavica·F Chaouloff
Aug 21, 1989·Brain Research·R S GreenwoodJ N Hayward
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
May 1, 1996·Pharmacology, Biochemistry, and Behavior·F G GraeffJ F Deakin
May 26, 1998·Epilepsy Research·R M AridaE A Cavalheiro
Mar 20, 2001·Archives of Neurology·D LaurinK Rockwood
Jun 28, 2002·Trends in Neurosciences·Carl W Cotman, Nicole C Berchtold
Aug 16, 2002·American Journal of Epidemiology·William J StrawbridgeGeorge A Kaplan
May 24, 2003·Sports Medicine·Jordan S Dubow, James P Kelly
Jan 30, 2004·International Journal of Sports Medicine·L J FulkG A Hand
Aug 5, 2004·Medicine and Science in Sports and Exercise·Katerina N Georgieva, Nickolay P Boyadjiev
Sep 6, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jiro MoriguchiSusumu Sasaki
Aug 1, 2006·Epilepsy Research·Zuzanna Setkowicz, Agnieszka Mazur
Mar 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ricardo Mario AridaEsper Abrão Cavalheiro
Mar 21, 2007·Epilepsy & Behavior : E&B·Andréy MazaratiRaman Sankar
Sep 25, 2007·Journal of Neurochemistry·Daniel KondziellaUrsula Sonnewald
Jan 22, 2008·Progress in Neurobiology·Munjal M AcharyaAshok K Shetty
Jun 19, 2008·Brain : a Journal of Neurology·Andréy MazaratiRaman Sankar
Apr 8, 2009·Trends in Neurosciences·Henriette van Praag
Apr 28, 2009·Neurochemistry International·Leonardo Magno RamboLuiz Fernando Freire Royes
Jan 14, 2010·Arquivos de neuro-psiquiatria·Fabio CamiloRicardo Mario Arida
Feb 18, 2010·Epilepsy & Behavior : E&B·Ricardo Mario AridaEsper Abrão Cavalheiro
Aug 31, 2010·Frontiers in Aging Neuroscience·Brenda J AndersonDaniel McCloskey
Nov 17, 2011·Neurobiology of Learning and Memory·Tzu-Wei LinChauying J Jen

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