PMID: 6409709Aug 1, 1983Paper

Effect of enkephalin and naloxone on gastric acid and serum gastrin and pancreatic polypeptide concentrations in humans

Gut
S J KonturekD H Coy

Abstract

The effects of a synthetic enkephalin analogue with prolonged opioid activity, D-ala-2-enkephalin (ala-enk) and naloxone given alone or in combination, on vagally, pentagastrin- and histamine-induced gastric secretion and plasma hormonal responses to vagal stimulation have been studied in healthy subjects. D-ala-2-enkephalin reduced basal gastric acid and pepsin secretion, and caused a dose-dependent inhibition of gastric secretory responses to modified sham-feeding and pentagastrin but not to histamine. It increased serum gastrin concentration and suppressed plasma pancreatic polypeptide response to modified sham-feeding. Naloxone alone at lower dose levels did not affect gastric secretion and plasma hormonal concentrations but at higher doses it reduced both basal and modified sham-feeding-induced secretion. When combined with ala-enk it reversed in part gastric secretory and plasma hormonal changes induced by this peptide during modified sham-feeding and pentagastrin stimulation. These results indicate that (1) stable enkaphalin analogue inhibits basal and vagally or pentagastrin-induced gastric secretion, and affects plasma hormonal response to vagal stimulation, at least in part, via activation of opioid receptors and (2) ...Continue Reading

References

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Jun 3, 1978·Lancet·P RedingP Barbier
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Citations

Oct 1, 1992·Digestive Diseases and Sciences·G TougasR H Hunt
Nov 19, 1985·European Journal of Pharmacology·G SoldaniD Bartolini
May 13, 1986·European Journal of Pharmacology·E Nishimura, C H McIntosh
Sep 23, 1988·European Journal of Pharmacology·M Chicau-ChovetC Rozé
Jan 1, 1988·Life Sciences·T F BurksF Porreca
Jul 1, 1988·Neuropeptides·W StapelfeldtM Classen
Oct 13, 2000·Gastroenterology Clinics of North America·K E McCollD Gillen
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·T Hedner, J Cassuto
May 1, 1989·The Journal of Pharmacy and Pharmacology·F De PontiA Crema
Apr 1, 1995·The Annals of Pharmacotherapy·B K WagnerA J Spotnitz
Aug 25, 2021·International Immunopharmacology·Hai HuangFengping Shan

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