Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers

Stroke; a Journal of Cerebral Circulation
Dermot CoxDesmond J Fitzgerald

Abstract

Aspirin resistance may be relatively common and associated with adverse outcome. Meta-analysis has clearly shown that 75 mg plain aspirin is the lowest effective dose; however, it is not known whether the recent increased use of enteric-coated aspirin could account for aspirin resistance. This study was designed to determine whether enteric-coated aspirin is as effective as plain aspirin in healthy volunteers. Seventy-one healthy volunteers were enrolled in 3 separate bioequivalence studies. Using a crossover design, each volunteer took 2 different aspirin preparations. Five aspirin preparations were evaluated, 3 different enteric-coated 75-mg aspirins, dispersible aspirin 75 mg and asasantin (25-mg standard release aspirin plus 200-mg modified-release dipyridamole given twice daily). Serum thromboxane (TX) B2 levels and arachidonic acid-induced platelet aggregation were measured before and after 14 days of treatment. All other aspirin preparations tested were inferior to dispersible aspirin (P<0.001) in their effect on serum TXB(2) level. Treatment failure (<95% inhibition serum TXB2 formation) occurred in 14 subjects, none of whom were taking dispersible aspirin. Mean weight for those demonstrating treatment failure was great...Continue Reading

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
May 14, 1987·The New England Journal of Medicine·Garret A FitzGerald
Nov 8, 1984·The New England Journal of Medicine·A K Pedersen, Garret A FitzGerald
Jun 1, 1982·The Journal of Clinical Investigation·P PatrignaniCarlo Patrono
Dec 1, 1995·Journal of Clinical Pharmacology·I H BenedekD M Kornhauser
Nov 10, 2000·BMJ : British Medical Journal·S Derry, Y K Loke
Aug 31, 2001·JAMA : the Journal of the American Medical Association·D MukherjeeEric J Topol
Apr 20, 2002·Science·Yan ChengGarret A FitzGerald
Aug 29, 2002·Alimentary Pharmacology & Therapeutics·A Van HeckenJ N De Hoon
May 4, 2005·Journal of Neurology·E L L M De SchryverDutch TIA trial and SPIRIT study groups
Sep 10, 2005·Journal of Thrombosis and Haemostasis : JTH·Andrew O MareeD J Fitzgerald
Oct 4, 2005·Journal of the American College of Cardiology·Andrew O MareeDesmond J Fitzgerald

Citations

Apr 18, 2008·Current Atherosclerosis Reports·Price Blair, Jane E Freedman
Feb 14, 2013·Journal of Cardiovascular Translational Research·Fabiana RolliniDominick J Angiolillo
Mar 3, 2007·Nature Clinical Practice. Cardiovascular Medicine·Andrew O MareeDesmond J Fitzgerald
Apr 9, 2009·Nature Reviews. Cardiology·Joseph M SweenyValentin Fuster
Dec 18, 2013·British Journal of Anaesthesia·A D Oprea, W M Popescu
Jan 5, 2013·Circulation Research·Desmond J Fitzgerald, Garret A FitzGerald
Nov 21, 2007·Hematology·Desmond J Fitzgerald, Andrew O Maree
Oct 20, 2010·Vascular Health and Risk Management·Juan V LlauAurelio Gómez-Luque
May 8, 2010·Vascular Health and Risk Management·Armen Yuri Gasparyan
Dec 27, 2008·Journal des maladies vasculaires·S RichardT Lecompte
Sep 3, 2013·Pharmacology & Therapeutics·Christopher N Floyd, Albert Ferro
Oct 26, 2012·Critical Reviews in Clinical Laboratory Sciences·Matthew D Linden, Huyen A Tran
Feb 11, 2011·Expert Review of Neurotherapeutics·Mehmet Akif TopçuogluHakan Ay
Nov 30, 2012·Expert Review of Cardiovascular Therapy·Rachel F PowerThomas J Kiernan
Mar 9, 2013·Expert Review of Cardiovascular Therapy·Piera Capranzano, Davide Capodanno
Mar 9, 2013·Expert Review of Cardiovascular Therapy·Bianca RoccaFrancesca Pagliaccia
Aug 2, 2012·Expert Opinion on Drug Metabolism & Toxicology·Marc BardouFrançoise Goirand
Jun 12, 2013·Expert Opinion on Drug Metabolism & Toxicology·Stavros ApostolakisEduard Shantsila
May 30, 2013·Hematology/oncology Clinics of North America·Paul Harrison, Marie Lordkipanidzé
May 29, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christian T DietzelAndreas Stallmach
Feb 8, 2011·Pharmacology & Therapeutics·Richard Fitzgerald, Munir Pirmohamed
Feb 18, 2010·Geriatric Nursing·Denise Bockwoldt
Sep 12, 2015·Future Cardiology·Kevin P BlidenPaul A Gurbel
Jul 25, 2015·Thrombosis Research·Craig J BeaversTracy E Macaulay
Feb 14, 2009·International Journal of Cardiology·Marie LordkipanidzéChantal Pharand
Jan 24, 2007·Thrombosis Research·Huyen A TranJohn W Eikelboom
Dec 13, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Xingyang YiLiFen Chi
Nov 22, 2014·Thrombosis and Haemostasis·R D MoriartyDermot Cox
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·Marco Cattaneo
Mar 10, 2009·Fundamental & Clinical Pharmacology·Victor L SerebruanyJames J Ferguson
Apr 11, 2012·Headache·Jill T JesurumSylvia M Lucas
Sep 16, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·F SantilliG Davì
Jul 27, 2010·Journal of Thrombosis and Haemostasis : JTH·Aaron PeaceDermot Cox
Dec 4, 2014·Basic & Clinical Pharmacology & Toxicology·Peter Fentz HaastrupDorte Ejg Jarbøl
Apr 10, 2010·Preventive Cardiology·Bryan C BordeauxDiane M Becker
Mar 26, 2016·Journal of the American College of Cardiology·Muthiah VaduganathanCOGENT Investigators
Jul 3, 2007·The American Journal of Medicine·Wai-Hong ChenChu-Pak Lau
Dec 17, 2015·Journal of Thrombosis and Haemostasis : JTH·R D MoriartyDermot Cox
Aug 10, 2012·Platelets·Marie Lordkipanidzé
Apr 15, 2015·Vascular Pharmacology·A A PettersenIngebjorg Seljeflot
Oct 18, 2008·Journal of the American College of Cardiology·John R Kapoor
Apr 25, 2015·Neurologic Clinics·Seby John, Irene Katzan
Jan 9, 2013·Current Opinion in Pharmacology·Charalampos KasmeridisGregory Y H Lip
May 12, 2012·Thrombosis Research·Chunjian LiJohn W Eikelboom
Feb 1, 2014·Journal of the Neurological Sciences·Aliaksei KisialiouCarmine Vecchione
Dec 4, 2014·Bioorganic & Medicinal Chemistry Letters·Machhindra GundApparao Satyam
Jan 14, 2011·Journal of Vascular Surgery·Justin SaundersELIMIT Investigators
Jun 21, 2016·Expert Opinion on Drug Metabolism & Toxicology·Ezekiel Uba Nwose, Kwang Choon Yee
May 9, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Nicole Dodge ZantekAlan T Hirsch
Sep 1, 2016·BMC Cardiovascular Disorders·Fathima Aaysha CaderMd Rezaul Karim
Apr 27, 2017·Cardiovascular Therapeutics·Nicholas B NorgardQing Ma
Jul 28, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Nikhil KapilAfshin A Divani
Jul 2, 2017·Basic & Clinical Pharmacology & Toxicology·Samah W Al-Jabi
Jan 1, 2012·Pharmaceuticals·Melania DovizioPaola Patrignani
Nov 16, 2017·Clinical Pharmacokinetics·Nicholas B Norgard
Jun 3, 2018·Journal of the American Heart Association·Joon-Tae KimKi-Hyun Cho
Jul 30, 2015·Stroke; a Journal of Cerebral Circulation·Joon-Tae KimKi-Hyun Cho
Apr 21, 2011·Circulation. Cardiovascular Interventions·Kevin P BlidenPaul A Gurbel
Jun 21, 2012·Circulation. Cardiovascular Interventions·José Luis Ferreiro, Dominick J Angiolillo
Apr 25, 2007·Circulation·Andrew O Maree, Desmond J Fitzgerald
Feb 15, 2019·Pediatric Blood & Cancer·Alexander A BoucherLori Luchtman-Jones
Apr 2, 2019·Journal of Thrombosis and Haemostasis : JTH·Giovanna PetrucciBianca Rocca
Sep 15, 2017·Clinical Pharmacology and Therapeutics·Dermot Cox, Desmond J Fitzgerald
Mar 18, 2019·Journal of Thrombosis and Thrombolysis·Remo H M FurtadoJose C Nicolau
Sep 21, 2018·Journal of Human Hypertension·Renuka ShanmugalingamAngela Makris
Nov 21, 2019·Molecular Medicine Reports·Ranjini SankaranarayananG Jayarama Bhat
Nov 23, 2020·The American Journal of Cardiology·Osama DasaThomas A Pearson
Dec 3, 2020·International Journal of Molecular Sciences·Ranjini SankaranarayananG Jayarama Bhat
Jun 14, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Daniela Amaral SilvaRaimar Löbenberg

Related Concepts

Asasantin
Zorprin
Novo-Dipiradol
Dose-Response Relationship, Drug
Drug Combinations
Platelet Aggregation
Platelet Inhibitors
Enteric Coated Tablet
Therapeutic Equivalency
Thromboxane B2

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