Effect of environmental conditions on production of toxic shock syndrome toxin 1 by Staphylococcus aureus.

Infection and Immunity
A C Wong, M S Bergdoll

Abstract

The kinetics of toxic shock syndrome toxin 1 (TSST-1) production by Staphylococcus aureus was studied in a fermentor in which aeration rate, atmospheric composition, pH, and temperature were controlled. The toxin was synthesized at a maximal rate during the exponential phase. High bacterial populations were not necessarily accompanied by high TSST-1 yields. Aerobiosis increased TSST-1 production, but excessive aeration had an adverse effect. Addition of CO2 enhanced TSST-1 yield by increasing toxin production rate and efficiency. Cultures with no pH control made more TSST-1 than those maintained at pH 5.5 to 7.5. Maximum TSST-1 yields were obtained when cultures were supplied with air (20 cm3/min) and CO2 (5 cm3/min) via a sintered glass sparger.

References

Apr 1, 1987·The Journal of Infectious Diseases·J K ToddD W Lawellin
Aug 1, 1987·Journal of Medical Microbiology·S K Sarafian, S A Morse
Jan 15, 1984·American Journal of Obstetrics and Gynecology·G WagnerL N Petersen
Aug 2, 1983·Biochemistry·R F ReiserM S Bergdoll
Feb 1, 1983·The Journal of Infectious Diseases·P M Schlievert, D A Blomster
Dec 1, 1982·Applied and Environmental Microbiology·R C FreedM S Bergdoll
Oct 1, 1958·Journal of Bacteriology·G A HUNTJ LEIN
Nov 1, 1966·Applied Microbiology·E KatoM S Bergdoll
Apr 1, 1983·Biotechnology and Bioengineering·A V Quirk, R W Plank
Mar 1, 1984·Journal of Food Protection·Ruth N Robbins, Merlin S Bergdoll

❮ Previous
Next ❯

Citations

Sep 7, 2001·Annual Review of Microbiology·J K McCormickP M Schlievert
Dec 4, 2004·Journal of Bacteriology·Brian WeinrickRichard P Novick
Jun 4, 2005·Journal of Applied Physiology·Donna R HillThomas W Osborn
Apr 3, 2004·Journal of Bacteriology·Alexa A PragmanPatrick M Schlievert
Jun 3, 2009·Microbiology and Molecular Biology Reviews : MMBR·Greg A Somerville, Richard A Proctor
Jan 15, 2013·Applied and Environmental Microbiology·Roderick A MacPheeGregor Reid
May 2, 2000·Journal of Clinical Microbiology·J M Yarwood, P M Schlievert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.