Effect of enzyme induction on nephrotoxicity of halothane-related compounds

Environmental Health Perspectives
B A Hitt, R I Mazze


Nephrotoxicity following administration of methoxyflurane has been shown to be directly related to anesthetic metabolism to inorganic fluoride. Enzyme induction should increase metabolic rate and the amount of inorganic fluoride that is released. In vivo studies in Fischer 344 rats show that enzyme induction with phenobarbital or phenytoin increases defluorination following methoxyflurane anesthesia but not after enflurane or isoflurane. In vitro, methoxyflurane defluorinase activity was increased far more than that of any of the other anesthetics. These data suggest that treatment with enzyme inducing drugs increases the risk of nephrotoxocity only if methoxyflurane is the anesthetic agent.


Jan 1, 1976·Anesthesiology·M J CousinsR I Mazze
Sep 1, 1974·The Journal of Pharmacology and Experimental Therapeutics·R I MazzeM J Cousins
Sep 24, 1973·JAMA : the Journal of the American Medical Association·M J Cousins, R I Mazze
Jan 1, 1974·The Journal of Pharmacology and Experimental Therapeutics·G A BarrJ C Kosek
Jun 1, 1974·Anesthesiology·R I MazzeG A Barr
Apr 12, 1971·JAMA : the Journal of the American Medical Association·R I MazzeS H Jackson
Oct 5, 1970·JAMA : the Journal of the American Medical Association·D R TavesA J Gillies
Sep 1, 1966·Anesthesiology·W B CrandellA Macdonald

Related Concepts

Anesthetic Effect
Metabolic Biotransformation
Environmental Exposure
Enzyme Induction
Kidney Diseases

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