Effect of Epimedium brevicornum Maxim extract on elicitation of penile erection in the rat

Urology
Kuang-Kuo Chen, Jen-Hwey Chiu

Abstract

To investigate the effect and mechanism of a Chinese medicine (Epimedium brevicornum Maxim [EbM]) on elicitation of penile erection in the rat. Adult male Sprague-Dawley rats were used. The penile intracavernous pressure (ICP) was monitored. Intracavernous administration of different doses (30, 100, 300, 1000, 3000, 6500, and 10,000 microg/0.1 mL) of EbM extract and saline 0.1 mL was done. Intracavernous NG-nitro-L-arginine methyl ester (L-NAME) (120 microg) was administered, followed by EbM extract 300 microg 10 minutes later. EbM extract (20, 10, and 10 microg) was stereotaxically delivered into the intracerebral ventricle, paraventricular nucleus of the hypothalamus, and hippocampus, respectively. After intracavernous administration of 30 or 100 microg EbM extract, no significant change in ICP was noted. All other doses (300 to 10,000 microg) of EbM extract elicited a significant increase in ICP, with the greatest peak at 99.7 +/- 0.3 mm Hg (resting 7.8 +/- 1.0 mm Hg) after application of 6500 microg EbM extract. No change in ICP occurred with administration of L-NAME followed by EbM extract. Furthermore, intracavernous saline or administration of EbM extract into the intracerebral ventricle, paraventricular nucleus of the h...Continue Reading

Citations

Sep 29, 2011·Current Urology Reports·Christopher C K Ho, Hui Meng Tan
Apr 10, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Haiyu ZhaoDean Guo
Mar 26, 2013·Journal of Biochemical and Molecular Toxicology·Jinwen LiuShuqiang Liu
Jan 11, 2011·Journal of Ethnopharmacology·Huiping MaZhengping Jia
Mar 26, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Syed NaseerKhursheed A Bhat
Apr 7, 2017·Phytotherapy Research : PTR·Jae-Heung ChoYoungmin Bu
Jan 29, 2020·Andrologia·Sunny O AbarikwuShio Kumar Singh
Jul 11, 2020·Journal of the Chinese Medical Association : JCMA·Hsin-Fu YehTa-Peng Wu

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