PMID: 8941533Nov 1, 1996Paper

Effect of episodic eucapnic and hypocapnic hypoxia on systemic blood pressure in hypertension-prone rats

Journal of Applied Physiology
E C Fletcher, G Bao

Abstract

Repetitive episodic (18-24 s twice per minute) hypocapnic hypoxia (HH) administered chronically (7 h/day, 35 days) to Sprague-Dawley or Wistar-Kyoto rats results in a sustained increase in daytime blood pressure (BP). We examined acute and chronic BP response to episodic HH and eucapnic hypoxia (EH) in borderline hypertensive rats [first generation (F1) cross between spontaneously hypertensive and Wistar-Kyoto rats]. We hypothesized that episodic HH and EH would create a greater increase in acute and chronic BP in this breed of rat than in previously studied strains. We also examined neural mechanisms by which BP changes from hypoxia are induced. BP and heart rate were examined acutely in nine F1 rats during baseline, HH, EH, EH with prazosin, and EH with prazosin and atropine. Five groups of male F1 rats were studied after 35-day exposure to the following: Unhandled (n = 8): no treatment; Sham (n = 10): episodic compressed air; HH (n = 14): daily episodic hypoxia (2.7%); EH1 (n = 12); hypoxia 2.9%, CO2 8.4%; and EH2 (n = 11): hypoxia 2.8% and CO2 10.5%. Under acute conditions, HH caused a 34.2-mmHg and EH a 77.9-mmHg increase in mean BP. Prazosin partially blocked the increase in BP. Under chronic conditions, HH caused a 10.3-...Continue Reading

References

Feb 1, 1992·Hypertension·T F LüscherZ H Yang
Dec 1, 1991·Journal of Pharmacological Methods·S Z KurowskiJ E Szilagyi
Jun 1, 1991·The Journal of Clinical Investigation·V K SomersF M Abboud
Oct 1, 1989·Journal of the Autonomic Nervous System·Y FukudaA Trzebski
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·J HednerG Wallin
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·J E LawlerS Oparil
Apr 1, 1985·Journal of Applied Physiology·R H CoxV P Mitchell
Aug 1, 1985·Annals of Internal Medicine·E C FletcherA B Gorin
Jul 1, 1995·Journal of Applied Physiology·B J MorganJ B Skatrud
Apr 1, 1994·Journal of Applied Physiology·R J KimoffE A Phillipson
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI

❮ Previous
Next ❯

Citations

Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L F Hayward
Sep 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chandra Sekhar BathinaSteve Mifflin
Feb 12, 1998·The American Journal of Physiology·V BorovskyD Ely
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·R S Leung, T D Bradley
Jul 9, 2005·Journal of Applied Physiology·M J CampenC P O'Donnell
Jun 3, 2008·Sleep Medicine Clinics·Jonathan Jun, Vsevolod Y Polotsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.