Abstract
Repetitive episodic (18-24 s twice per minute) hypocapnic hypoxia (HH) administered chronically (7 h/day, 35 days) to Sprague-Dawley or Wistar-Kyoto rats results in a sustained increase in daytime blood pressure (BP). We examined acute and chronic BP response to episodic HH and eucapnic hypoxia (EH) in borderline hypertensive rats [first generation (F1) cross between spontaneously hypertensive and Wistar-Kyoto rats]. We hypothesized that episodic HH and EH would create a greater increase in acute and chronic BP in this breed of rat than in previously studied strains. We also examined neural mechanisms by which BP changes from hypoxia are induced. BP and heart rate were examined acutely in nine F1 rats during baseline, HH, EH, EH with prazosin, and EH with prazosin and atropine. Five groups of male F1 rats were studied after 35-day exposure to the following: Unhandled (n = 8): no treatment; Sham (n = 10): episodic compressed air; HH (n = 14): daily episodic hypoxia (2.7%); EH1 (n = 12); hypoxia 2.9%, CO2 8.4%; and EH2 (n = 11): hypoxia 2.8% and CO2 10.5%. Under acute conditions, HH caused a 34.2-mmHg and EH a 77.9-mmHg increase in mean BP. Prazosin partially blocked the increase in BP. Under chronic conditions, HH caused a 10.3-...Continue Reading
References
Nov 1, 1992·Hypertension·E C FletcherT Unger
Jun 1, 1992·Hypertension·E C FletcherT Unger
May 1, 1992·Journal of Applied Physiology·E C FletcherT Unger
Feb 1, 1992·Hypertension·T F LüscherZ H Yang
Dec 1, 1991·Journal of Pharmacological Methods·S Z KurowskiJ E Szilagyi
Jun 1, 1991·The Journal of Clinical Investigation·V K SomersF M Abboud
Oct 1, 1989·Journal of the Autonomic Nervous System·Y FukudaA Trzebski
Nov 1, 1989·Journal of Applied Physiology·V K SomersF M Abboud
Mar 1, 1989·Brain Research Bulletin·V P Mitchell, J E Lawler
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·J HednerG Wallin
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·J E LawlerS Oparil
Feb 1, 1987·Sleep·E C FletcherJ G Fletcher
Apr 1, 1985·Journal of Applied Physiology·R H CoxV P Mitchell
Aug 1, 1985·Annals of Internal Medicine·E C FletcherA B Gorin
Sep 1, 1972·Circulation Research·C L Pelletier
Jan 1, 1984·Physiology & Behavior·J E LawlerG W Randall
Jul 1, 1981·Hypertension·J E LawlerR G Schaub
Jul 1, 1995·Journal of Applied Physiology·B J MorganJ B Skatrud
Apr 1, 1995·Journal of Applied Physiology·E C FletcherC C Miller
Feb 1, 1995·The American Journal of Medicine·E C Fletcher
Apr 1, 1994·Journal of Applied Physiology·R J KimoffE A Phillipson
Mar 1, 1993·Chest·O MarroneM R Bonsignore
Sep 1, 1995·Genome Research·N J SchorkH J Jacob
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Citations
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L F Hayward
Sep 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chandra Sekhar BathinaSteve Mifflin
Aug 8, 2015·Journal of Applied Physiology·J Woodrow WeissYuzhen Liu
Feb 12, 1998·The American Journal of Physiology·V BorovskyD Ely
May 18, 2001·Journal of Applied Physiology·K A Fagan
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·R S Leung, T D Bradley
Jul 9, 2005·Journal of Applied Physiology·M J CampenC P O'Donnell
Apr 28, 2004·Experimental Physiology·Aidan Bradford
Oct 20, 2007·Journal of Applied Physiology·Jessica B SnowThomas C Resta
Aug 21, 2014·Basic Research in Cardiology·Mikiyasu ShiraiDaryl O Schwenke
Mar 6, 1998·Journal of Hypertension·J LesskeT Unger
Oct 29, 2014·PloS One·Hisashi NagaiMikiyasu Shirai
Dec 22, 1999·Journal of Applied Physiology·H KraicziJ Hedner
Jul 16, 2011·Journal of Applied Physiology·Charles E NortonThomas C Resta
Jun 3, 2008·Sleep Medicine Clinics·Jonathan Jun, Vsevolod Y Polotsky