Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and corticosteroid-treated rats.

Lasers in Medical Science
P GálJ Sabo

Abstract

Optimal parameters of low-level laser therapy (LLLT) for wound healing are still discussed. Hence, our study was aimed to compare effects of different power densities of LLLT at 635 nm in rats. Four, round, full-thickness, skin wounds were made on the backs of 48 rats that were divided into two groups (non-steroid laser-treated and steroid laser-treated). Three wounds were stimulated daily with a diode laser (daily dose 5 J/cm(2)) each with different power density (1 mW/cm(2), 5 mW/cm(2), and 15 mW/cm(2)), whereas the fourth wound served as a control. Two days, 6 days, and 14 days after surgery, eight animals from each group were killed and samples were removed for histological evaluation. In the non-steroid laser-treated rats, significant acceleration of epithelization and collagen synthesis 2 days and 6 days after surgery was observed in stimulated wounds. In steroid laser-treated rats, 2 days and 14 days after surgery, a decreased leucocyte/macrophage ratio and a reduction in the area of granulation tissue were recorded, respectively. In conclusion, LLLT, by the method we used, improved wound healing in the non-steroid laser-treated rats, but it was useless after corticosteroid treatment.

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Citations

Aug 25, 2009·Photomedicine and Laser Surgery·Mohammad Mehdi VasheghaniFatemehsadat Rezaei
Sep 22, 2009·Photomedicine and Laser Surgery·Lucio FrigoRodrigo Alvaro Brandão Lopes-Martins
Jun 3, 2011·Photomedicine and Laser Surgery·Marco MozzatiRosa Angela Canuto
Apr 19, 2012·Photomedicine and Laser Surgery·Milena Góes da GuardaLuciana Maria Pedreira Ramalho
Apr 23, 2013·Photomedicine and Laser Surgery·Tiina Karu
Jun 28, 2012·Journal of Biomedical Optics·Chung-Ku RheeMyung-Whan Suh
Mar 25, 2014·The American Journal of Pathology·James D Carroll
Sep 11, 2012·International Wound Journal·Rachel L-C KwanSing K Lo
Aug 28, 2015·Journal of Photochemistry and Photobiology. B, Biology·PikSuan LauAsmah Hamid
Jan 1, 2011·Dose-response : a Publication of International Hormesis Society·Ying-Ying HuangMichael R Hamblin
Feb 19, 2015·Photomedicine and Laser Surgery·Eduardo Henrique LoretiDiego França Pedrosa
Jul 3, 2016·Lasers in Medical Science·Hakan SolmazYekta Ulgen
Jan 27, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·M E OliveiraM Chacur
Oct 31, 2019·Lasers in Medical Science·T F De MoraesG J Rodrigues
Jun 22, 2019·Lasers in Medical Science·Victória Regina da Silva OliveiraCamila Squarzoni Dale
Feb 15, 2020·Oral and Maxillofacial Surgery·Gustavo Antonio Correa MomessoEduardo Piza Pellizzer
Feb 25, 2017·International Journal of Oral Science·Mei-Chun YehYan-Hsiung Wang
Mar 23, 2017·Lasers in Medical Science·Hakan SolmazMurat Gulsoy
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Dec 15, 2018·Journal of Biomedical Optics·Randa ZeinMichael R Hamblin
Oct 31, 2014·International Journal of Clinical Pediatric Dentistry·Marco PaschoalCyneu Pansani

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