Effect of eradication of Helicobacter pylori on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: a controlled trial

American Journal of Hematology
Nematollah RostamiFatemeh Soghra Esfahani

Abstract

Several recent studies have suggested that an association exists between Helicobacter pylori (HP) eradication and improvement in platelet count in a significant proportion of patients with idiopathic thrombocytopenic purpura (ITP). In this controlled study, we prospectively examined adult patients with chronic ITP for HP infection, and assessed the effect of HP eradication on platelet count. One hundred forty-two consecutive Iranian patients with chronic ITP were assessed. Those who met the criteria and had platelet counts >30 x 10(9)/L within the medication-free screening month were enrolled (n = 129; 66 females; mean age, 29.2 +/- 7.0 years). HP-positive patients received a 2-week course of triple HP eradication therapy (i.e., amoxicillin, clarithromycin, and omeprazole) and were followed for 48 weeks. An ITP response was defined as a platelet count of >100 x 10(9)/L 24 weeks after treatment, together with an increase in the platelet count >30 x 10(9)/L over the baseline value. HP infection was detected in 79 (61%) patients. HP-positive patients were significantly older than HP-negative subjects (P = 0.018). HP eradication was successful in 87% (62/71) of those who completed the eradication therapy. Whereas 48% (30/62) of HP-...Continue Reading

References

Jul 2, 1998·Journal of Clinical Gastroenterology·D A de LuisD Boixeda
Feb 17, 2000·Seminars in Hematology·R McMillan
May 15, 2002·Archives of Internal Medicine·Marc MichelPhilippe Bierling
Aug 30, 2002·British Journal of Haematology·Giovanni EmiliaGiuseppe Torelli
Oct 11, 2002·The New England Journal of Medicine·Sebastian Suerbaum, Pierre Michetti
Jul 9, 2004·World Journal of Gastroenterology : WJG·Erdal KurtogluAysegul Ugur
Mar 16, 2005·International Journal of Hematology·Kingo Fujimura
Apr 6, 2005·The American Journal of Medicine·Roberto StasiDrew Provan
Nov 2, 2005·Pediatric Blood & Cancer·Tang-Her JaingI-Anne Huang
Jan 20, 2006·Platelets·Massimo Franchini, Dino Veneri
Sep 29, 2006·World Journal of Gastroenterology : WJG·Mahmood Reza HashemiMohsen Dehghani Zahedani
Nov 23, 2006·International Journal of Hematology·Masataka Kuwana, Yasuo Ikeda

❮ Previous
Next ❯

Citations

Jan 26, 2013·Epidemiologic Reviews·Francis Mawanda, Robert Wallace
Feb 11, 2016·World Journal of Clinical Pediatrics·Li-Jing Xiong, Meng Mao
Oct 4, 2014·World Journal of Gastroenterology : WJG·Germán Campuzano-Maya
Feb 8, 2020·Clinical and Translational Gastroenterology·Da Sol ChoiChan Hyuk Park
Mar 26, 2011·Journal of Thrombosis and Haemostasis : JTH·D CoxS P Watson
Mar 15, 2020·Digestive Diseases and Sciences·Bernardo Guevara, Asha Gupta Cogdill
Sep 12, 2008·Helicobacter·Hilde MoyaertAntonio Gasbarrini
Nov 8, 2018·Gastroenterology Research and Practice·Bum Jun KimJung Han Kim
Feb 15, 2017·Gastroenterology Research and Practice·Khan SheemaSheikh Imran
Mar 21, 2019·The New England Journal of Medicine·Sheila E Crowe
Mar 13, 2021·Blood Research·Seyed Mohammad Sadegh PezeshkiArshid Yousefi Avarvand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.