Effect of ERK inhibitor on pulmonary metastasis of inoculated human adenoid cystic carcinoma cells in nude mice

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Ji-an HuJinhua Fang

Abstract

In this study, we detected the expression of phosphylated ERK1/2 in human salivary adenoid cystic carcinoma (SACC) by immunohistochemical method, the effect of various concentrations of PD98059 on the growth of ACC-M cells (a cell line of human adenoid cystic carcinoma of the salivary glands) by MTT assay, and the effect of PD98059 on the lung metastasis of inoculated ACC-M cells in nude mice. The results showed that the phosphylated ERK1/2 was overexpressed in SACC, the ACC-M cell line proliferation was inhibited by PD98059, and the lung metastasis level was reduced by PD98059, indicating that ERK may be a key molecule in targeted therapy of adenoid cystic carcinoma.

References

Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·D T DudleyA R Saltiel
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G PagèsJ Pouysségur
Apr 1, 1997·Current Opinion in Cell Biology·M J Robinson, M H Cobb
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ItoM Hori
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·C P WebbG F Vande Woude
Apr 21, 1999·Current Opinion in Cell Biology·T P Garrington, G L Johnson
Jul 2, 1999·International Journal of Cancer. Journal International Du Cancer·K B ReddyC A Diglio
Aug 24, 1999·Molecular and Cellular Biology·T H HolmströmJ E Eriksson
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Baljinder SalhSteven Pelech
Sep 23, 2003·Cell Death and Differentiation·S E F TranJ E Eriksson
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Leigh MurphyPeter Watson
Oct 16, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Yasunori TsuboiYutaka Aoyagi
Nov 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melissa R JunttilaJukka Westermarck
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Meera V Sundaram
Dec 7, 2007·Developmental Cell·Esther M Verheyen
Apr 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nabil F Saba, Stuart J Wong

❮ Previous
Next ❯

Citations

Oct 28, 2014·The Journal of Clinical Investigation·Yosuke FunatoHiroaki Miki
Jul 22, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Eveline GrunderMichael Grotzer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Related Papers

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Hong ShiHe-xiang Li
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Feng-hao HuangJiang Li
The Chinese Journal of Dental Research : the Official Journal of the Scientific Section of the Chinese Stomatological Association (CSA)
Z GuX Zhou
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Bing-zhi YanXu Wang
© 2021 Meta ULC. All rights reserved