PMID: 30173462Sep 3, 2018Paper

Effect of Erxian Decoction on cyclophosphamide-induced oligospermia in mice

Zhonghua nan ke xue = National journal of andrology
Bo LiuZhi-Wen Liu

Abstract

To study the effect of Erxian Decoction (EXD) on oligospermia (OS) induced by cyclophosphamide in mice. Eighty 6-week-old male Kunming mice were randomly divided into five groups of equal number, normal control, OS model control, and low-, medium- and high-dose EXD, the former two groups treated intragastrically with normal saline and the latter three with EXD at 3, 6 and 12 g per kg of the body weight qd for 30 days. From the 21st day of administration, the mice of the normal control group were injected intraperitoneally with saline and those of the other four groups with cyclophosphamide at 80 mg per kg of the body weight qd for 5 consecutive days. At 24 hours after the last gavage, the bilateral epididymides of the mice were collected and sperm suspension prepared for determination of the sperm count and motility, and the bilateral testes were harvested for histomorphological observation and measurement of the concentrations of superoxide dismutase (SOD), malondialdehyde (MAD) and glutathione (GSH) in the testis tissue. Compared with the normal controls, the mice of the OS model control group showed significant decreases in epididymal sperm concentration ([9.31 ± 1.32] vs [3.32 ± 1.13]×107/ml, P <0.01) and motility ([44.75 ±...Continue Reading

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