PMID: 9430010Jan 16, 1998Paper

Effect of erythromycin on gastric emptying in healthy individuals assessed by radio-opaque markers and plasma acetaminophen levels

Journal of Gastroenterology
H J ParkI S Park

Abstract

We simultaneously recorded gastric emptying of radio-opaque markers (ROMs) and monitored serial changes in plasma acetaminophen (AAP) levels to demonstrate the relationship between the ROM and the AAP methods, and we investigated the effect of a single intravenous dose of erythromycin (EM) on gastric emptying in healthy human subjects. After an overnight fast, subjects were randomized to receive either placebo or EM lactobionate (Abbott, North Chicago, IL, USA) 250 mg intravenously in a single dose, given immediately before a standard meal. Subjects ingested 1.5 g of AAP and ROMs with the test meal. A supine plain abdominal radiograph was taken 1, 2, 3, and 6 h after ingestion of the test meal. Peripheral blood samples were obtained 0, 0.5, 1, 1.5, 2, 3, and 6 h after ingestion of the test meal. EM significantly accelerated gastric emptying of ROMs. By 6 h, no markers remained in the stomach in any of the subjects in the placebo or EM groups. By 120 min, half of the ROMs had passed into the duodenum in 12.5% of subjects after placebo, whereas EM injection resulted in gastric emptying of half of the ROMs in all subjects. There was no difference in plasma AAP concentration between the placebo and EM groups. There were significant...Continue Reading

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Citations

Feb 8, 2006·Journal of Gastroenterology and Hepatology·Seung Hyun ChoJeffrey L Conklin
Jul 27, 2010·Journal of Visceral Surgery·S BerthetJ Y Mabrut
Jun 13, 2014·Fundamental & Clinical Pharmacology·Sonia GoineauVincent Castagné
Sep 25, 2017·Journal of Veterinary Internal Medicine·I M BalsaS L Marks
Aug 20, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S SchaerA Steiner
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshitaka ToyomasuHiroyuki Kuwano

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