Effect of erythromycin on microbial antagonisms: a study in gnotobiotic mice associated with a human fecal flora

The Journal of Infectious Diseases
A AndremontC Tancrede

Abstract

The effect of erythromycin base was studied on intestinal resistance to colonization of gnotobiotic mice inoculated with a human fecal flora and challenged with six microbial strains potentially pathogenic for immunocompromised patients. Fecal concentrations of erythromycin were greater than 1,000 micrograms/g in the human donor and in mice. Total intestinal bacterial counts were not significantly different in the human donor and in the recipient mice and were not affected by erythromycin treatment. Strains of various species from the dominant flora (greater than 10(9) colony-forming units/g) and resistant to greater than 1,000 micrograms of erythromycin/ml were present before and persisted during treatment. Strains sensitive to such concentrations - particularly all enterobacteria-were eliminated. Treatment did not reduce colonization resistance against Candida albicans, Clostridium perfringens, and erythromycin-sensitive Escherichia coli. It reduced but did not eliminate some colonization resistance against Pseudomonas aeruginosa, Clostridium difficile, and erythromycin-resistant E coli.

Citations

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·C J Rumney, I R Rowland
Mar 1, 1986·Antimicrobial Agents and Chemotherapy·A AndremontP Courvalin
Nov 1, 1986·Antimicrobial Agents and Chemotherapy·M Arthur, P Courvalin
Jan 1, 1987·Antimicrobial Agents and Chemotherapy·S PecquetC Tancrède
Apr 1, 1987·Antimicrobial Agents and Chemotherapy·D E Corpet
Aug 1, 1989·Antimicrobial Agents and Chemotherapy·A AndremontC Hill
May 1, 1993·Antimicrobial Agents and Chemotherapy·M E GordilloB E Murray
Jun 1, 1985·The Journal of Applied Bacteriology·F LeonardC Tancrede
Oct 18, 2001·Regulatory Toxicology and Pharmacology : RTP·A Perrin-GuyomardJ M Poul
Jul 2, 1999·Regulatory Toxicology and Pharmacology : RTP·C E Cerniglia, S Kotarski
Sep 1, 1985·Infection and Immunity·A AndremontP Courvalin
Apr 1, 1988·Journal of Bacteriology·A Brisson-NoëlP Courvalin
Mar 1, 1986·Annales De L'Institut Pasteur. Microbiology·M ArthurP Courvalin

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