PMID: 16502766Mar 1, 2006Paper

Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers

International Journal of Clinical Pharmacology and Therapeutics
Niclas PetriHans Lennernäs

Abstract

To investigate the in vivo intestinal absorption mechanism(s) and systemic availability of fexofenadine in the jejunum, ileum and colon in humans. A single dose of fexofenadine hydrochloride (60 mg as solution) was applied under fasting conditions, either alone or directly after a solution of erythromycin lactobionate (corresponding to a dose of 250 mg erythromycin), to the jejunum, ileum and colon in 6 healthy volunteers (3 male and 3 female) using a regional intubation dosing technology (Bioperm AB, Lund, Sweden). A total of 36 fexofenadine administrations were performed. The administration of fexofenadine to the specified location either alone or in combination with erythromycin was conducted in a randomized manner on 2 consecutive days with a 5-day washout period between doses. The plasma AUC for fexofenadine (mean +/- SEM) was higher (2.7-to 2.3-fold, p < 0.001) after application to the jejunum (1090 +/- 134 h x ng/ml) than to the ileum (404 +/- 102 h x ng/ml) or colon (476 +/- 212 h x ng/ml). No significant differences were found between application to the ileum and colon. The administration of erythromycin affected the absorption rate after jejunal application with a prolonged tmax from a median of 40 min (range 10-90 mi...Continue Reading

Citations

Feb 13, 2009·Current Allergy and Asthma Reports·Lawrence DuBuske, Krzysztof Kowal
Jun 4, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Erik SjögrenChrister Tannergren
May 20, 2015·Journal of Pharmaceutical Sciences·Shinji SakumaKohsaku Kawakami
Oct 31, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H Lennernäs
Oct 31, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S OswaldH K Kroemer
Jul 8, 2008·International Journal of Pharmaceutics·Emma L McConnellAbdul W Basit
Mar 6, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Lars NybergOlof Borgå
Nov 26, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Arik DahanGordon L Amidon
Aug 10, 2016·Molecular Pharmaceutics·David DahlgrenHans Lennernäs
Feb 1, 2007·Journal of Neurochemistry·Laszlo TretterVera Adam-Vizi
Sep 19, 2017·Expert Opinion on Drug Discovery·Teruo Murakami
Jul 7, 2017·The AAPS Journal·Rong-Kun ChangMunir A Hussain

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