PMID: 2095341Jan 1, 1990Paper

Effect of erythromycin on the oro-caecal transit time in man

European Journal of Clinical Pharmacology
J LehtolaA Gordin

Abstract

Erythromycins often cause gastrointestinal side-effects due to an increase in motility or to change in the intestinal bacterial flora. In order to evaluate the effect of erythromycin on gastrointestinal motility. 11 healthy volunteers were given placebo, erythromycin stearate (ES) 1000 mg or a therapeutically equivalent single dose of erythromycin acistrate (EA.2'-acetyl erythromycin stearate) 800 mg in a double-blind trial. The oro-caecal transit time was measured using the hydrogen breath test with lactulose as the substrate. The transit time was estimated from the H2-peak (ppm) in end-expiratory breath by two methods, t1 representing the "front" and t2 the "bulk" of lactulose reaching the colon. t1 was 51 min in the placebo group, 38 min in the EA and 31 min in the ES group (p less than 0.05, ES vs placebo). t2 was 74 min, 64 min, and 46 min, respectively (p less than 0.05, ES vs placebo). The difference between EA and ES was also significant. Six subjects in the ES group but none in the EA group recorded adverse gastrointestinal effects attributable to medication. It was concluded that erythromycin shortens the oro-caecal transit time in man and that EA effects the transit time slightly less than ES.

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Citations

Oct 12, 2012·Pharmaceutical Research·Tohru KokuboMakio Ishiguro
May 1, 2001·Alimentary Pharmacology & Therapeutics·J I CurryM D Stringer
Apr 1, 1995·Pharmacology & Toxicology·H LuurilaP J Neuvonen
Feb 1, 1996·Pharmacology & Toxicology·H LuurilaP J Neuvonen
May 5, 2004·Best Practice & Research. Clinical Gastroenterology·Laurent Beaugerie, Jean-Claude Petit
Feb 13, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G Van AsscheT L Peeters
Jul 4, 2018·Journal of Neurogastroenterology and Motility·Hirokazu FukuiHiroto Miwa
Oct 1, 1994·The British Journal of Surgery·M A Pilot
Jan 27, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·O ChassanyJ F Bergmann
Feb 18, 2006·Scandinavian Journal of Gastroenterology·Patrick P J Van Der VeekAd A M Masclee
Nov 7, 2017·Frontiers in Neuroscience·Thilini DelungahawattaWolfgang A Kunze
Apr 27, 2002·American Journal of Surgery·Aviram NissanMenachem Hanani

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