PMID: 7031111Dec 1, 1981Paper

Effect of erythromycin on theophylline kinetics

The Journal of Allergy and Clinical Immunology
R A PrinceS Riegelman

Abstract

The effect of erythromycin base on theophylline kinetics was studied in eight informed, nonsmoking, adult males who received a 15-min infusion of theophylline (aminophylline) 5 mg/kg, prior to (control) and after (experimental) a 7-day course of 1 gm daily erythromycin base (E-Mycin). Each subject acted as his own control. Multiple serum samples were collected for 24 hr after each dose and were analyzed for theophylline by high-pressure liquid chromatography. The mean +/- SD pharmacokinetic parameters for each phase of study were as follows: apparent volume of distribution (L/kg) 0.45 +/- 0.05 (control), 0.41 +/- 0.05 (experimental); clearance (ml . min/kg) 0.83 +/- 0.17 (control), 0.60 +/- 0.11 (experimental); elimination half-life (hr) 6.65 +/- 1.88 (control), 8.10 +/- 1.58 (experimental). Erythromycin significantly affected the elimination half-life and clearance of theophylline (p less than 0.05). The apparent volume of distribution was unaffected (p greater than 0.05). Therefore patients being administered theophylline appear to be at added risk for the development of toxicity when erythromycin is added to the therapeutic regimen.

References

Aug 1, 1977·The Journal of Allergy and Clinical Immunology·P P KozakS H Gillman
Sep 20, 1973·The New England Journal of Medicine·P A Mitenko, R I Ogilvie
Jul 1, 1981·The Journal of Pediatrics·C F LaForceH Chai

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Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·N PrincipiA Vigano
Jan 1, 1987·European Journal of Clinical Pharmacology·M GartyI Varsano
Feb 21, 1986·Pharmaceutisch Weekblad. Scientific Edition·W J WijnandsC L Van Herwaarden
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Dec 3, 2014·Frontiers in Human Neuroscience·Anna Craig-McQuaideElina Tripoliti
Jan 1, 1988·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M J Rieder, M Spino
Jan 1, 1983·Pharmacotherapy·L Hendeles, M Weinberger
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Jul 30, 2020·Clinical Pharmacokinetics·Jasleen K SodhiLeslie Z Benet
Jan 1, 1988·Annals of Clinical Biochemistry·D J RoweD J Berry
Jul 1, 1989·Current Problems in Pediatrics·D NeddenriepR J Lemen

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