Effect of erythropoietin-stimulating agent on uremic inflammation.

Journal of Inflammation
Yuri TanakaTakashi Shigematsu

Abstract

The goal of the present study was to explore the effect of medications that are commonly prescribed for CKD patients on uremic state. This was a cross-sectional study. From January 2006 to October 2009, 1,623 patients with end-stage kidney disease (ESKD) commenced hemodialysis (HD) at the 9 participating hospitals. The criteria for exclusion from the database were 1) serum C-reactive protein (CRP) > 3 mg/dL, 2) WBC count > 9,000/mm3 or <4,000/mm3, and 3) patients with cancer, immune complex disease, or vasculitis. A total of 900 patients were entered into the final database. We explored the association of serum CRP just before the first HD session with clinical characteristics, laboratory data, and medications for CKD in the predialysis period. On univariate analysis, age, CTR, eGFR, and WBC were significantly correlated with CRP. Systolic and diastolic blood pressure, serum albumin, LDL-C, HDL-C, Hb, Cr, and Ca were inversely associated with CRP. Use of erythropoietin-stimulating agents (ESA) using (r = -0.111, p = 0.0015), renin-angiotensin-aldosterone system inhibitors (r = -0.083, p = 0.0154), and calcium channel blockers (r = -0.1, p = 0.0039) was also negatively correlated with CRP. However, only use of ESA showed a signi...Continue Reading

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Citations

Jul 14, 2017·American Journal of Physiology. Renal Physiology·Jeroen P KoomanPeter Stenvinkel
Jun 22, 2017·Journal of Renal Care·Ahmad F ThabetMedhat A Saleh
Sep 10, 2018·Clinical and Experimental Nephrology·Shun KuboNobuhiko Joki
May 20, 2021·Antioxidants & Redox Signaling·Thomas EbertPaul G Shiels

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