PMID: 3772153Nov 1, 1986Paper

Effect of essential fatty acid deficiency on cutaneous sterol synthesis

The Journal of Investigative Dermatology
K R FeingoldP M Elias

Abstract

The fact that the skin is a major site of total body sterologenesis, coupled both with the apparent absence of low density lipoprotein receptors on keratinocytes and with the lack of influence of serum cholesterol on epidermal sterologenesis, has created the impression that epidermal lipid synthesis might be autonomous, i.e., nonregulatable. Recent studies have shown, however, that disruption of cutaneous barrier function with acetone or detergents stimulates epidermal sterologenesis (J Lipid Res 26:418-427, 1985). To correlate further sterologenesis with barrier function, we measured de novo synthesis of cholesterol and total nonsaponifiable lipids in essential fatty acid-deficient (EFAD) hairless mice. Animals with defective barrier function, manifested by abnormal transepidermal water loss, demonstrated a 2-fold increase in epidermal cholesterol and total nonsaponifiable lipid synthesis over controls while synthesis in the dermis was unchanged. Epidermal sterologenesis in EFAD animals, repleted with linoleic acid either systematically or topically, returned toward normal as barrier function improved. Moreover, plastic occlusion of EFAD mouse skin normalized epidermal sterologenesis at 1 and 3 days. These results provide furt...Continue Reading

References

Feb 1, 1977·The British Journal of Dermatology·N J Lowe, R B Stoughton
May 1, 1976·The British Journal of Dermatology·C Prottey
Jan 1, 1969·The British Journal of Dermatology·H J Yardley
Aug 1, 1983·The Journal of Investigative Dermatology·M PonecB J Vermeer
Oct 1, 1983·The Journal of Investigative Dermatology·K R FeingoldP M Elias
Jan 1, 1983·Metabolism: Clinical and Experimental·K R FeingoldM D Siperstein

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Citations

Nov 1, 1996·The Journal of Dermatology·P M Elias
Nov 5, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·M Lodén
Jan 1, 1990·Archives of Dermatological Research·B MelnikG Plewig
Feb 1, 1994·The British Journal of Dermatology·G K MenonK R Feingold
Jan 1, 1995·Archives of Dermatological Research·S MottaM Monti
Sep 10, 2005·Journal of Lipid Research·Biao LuKenneth R Feingold
Jan 1, 1988·Annals of the New York Academy of Sciences·P M Elias, K R Feingold
Feb 8, 2007·Bioscience, Biotechnology, and Biochemistry·Michio NakaharaTakashi Hayakawa
Sep 6, 2001·Clinics in Dermatology·P MorgantiV Ruocco
Sep 14, 1987·Biochimica Et Biophysica Acta·K R FeingoldP M Elias
Feb 1, 1992·The Journal of Investigative Dermatology·G K MenonP M Elias
Feb 1, 1991·The Journal of Investigative Dermatology·K R FeingoldP M Elias
Jun 1, 1994·The Journal of Investigative Dermatology·S H LeeT Mauro
Oct 1, 1996·The Journal of Investigative Dermatology·R GhadiallyP M Elias
May 1, 1994·The Journal of Investigative Dermatology·S Wu-PongK R Feingold
Jun 1, 1992·The Journal of Investigative Dermatology·M PonecB J Vermeer
Mar 11, 2004·The Journal of Investigative Dermatology·Chantel O BarlandRuby Ghadially
Mar 27, 2002·Clinics in Geriatric Medicine·Peter M Elias, Ruby Ghadially
May 1, 1989·The American Journal of the Medical Sciences·B R MeyerD Sibalis
Mar 1, 1992·Journal of the American Academy of Dermatology·R GhadiallyP M Elias

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