PMID: 1576671Jan 1, 1992Paper

Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells

Chemical & Pharmaceutical Bulletin
Y SatoK Ichinoseki

Abstract

The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 microM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

Citations

Apr 1, 1997·Environmental Health Perspectives·T Tsutsui, J C Barrett
Oct 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C WestmorelandP Grasso
Feb 20, 2002·Drug and Chemical Toxicology·Taiko OdaYoshihiro Sato
Jul 1, 2016·Endocrine-related Cancer·Milena Rondón-LagosAnna Sapino
Jun 5, 2004·Toxicology Letters·H F P JoostenE I Krajnc
Oct 20, 2001·Biological & Pharmaceutical Bulletin·T OdaT Sasaki
Mar 4, 2008·Chemical & Pharmaceutical Bulletin·Magie Melanie KapojosMichio Namikoshi

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