Effect of estradiol on fibroblasts from postmenopausal idiopathic carpal tunnel syndrome patients.

Journal of Cellular Physiology
Yoshiaki YamanakaAkinori Sakai

Abstract

Fibrosis of the subsynovial connective tissue (SSCT) is a characteristic finding in patients with idiopathic carpal tunnel syndrome (CTS). Idiopathic CTS frequently occurs in postmenopausal women; therefore, female steroid hormones, especially estrogens, may be involved in its development. In this study, we evaluated the effect of the estradiol on the expression of genes and proteins related to fibrosis of SSCT fibroblasts from patients with idiopathic CTS. This study included 10 postmenopausal women (mean age 76 years). Fibroblasts derived from SSCT were treated with estradiol (10-4 -10-12  M), and the expression levels of TGF-β-responsive genes were evaluated. The relationships between the expression of untreated estrogen receptor α (ERα) and ERβ and changes in gene expression due to estradiol treatment were examined by quantitative real-time polymerase chain reaction. The effects of 10-4  M estradiol on collagen type I (Col1) and collagen type III (Col3) protein expression levels were also evaluated by fluorescent staining. The relationships between ERα/β and Col1/3 expression were evaluated by immunohistochemical staining. The reduction in Col1A1 mRNA expression due to estradiol treatment was positively correlated with ERα ...Continue Reading

References

Oct 1, 1975·Annals of the Rheumatic Diseases·W H AkesonL Rutherford
Apr 1, 1992·Journal of Clinical Epidemiology·M C de KromF Spaans
Dec 1, 1990·American Journal of Epidemiology·M C de KromF Spaans
May 1, 1994·The Journal of Bone and Joint Surgery. American Volume·R J MajeskaT A Einhorn
Jul 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S H LiuJ M Lane
Sep 1, 1997·Obstetrics and Gynecology·M L MokrzyckiR I Demopolous
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YasudaS Ito
Feb 24, 2001·Clinical Orthopaedics and Related Research·W D YuG A Finerman
Nov 26, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·J D P Bland, S M Rudolfer
Jul 15, 2004·The Journal of Bone and Joint Surgery. American Volume·Anke M EttemaKai-Nan An
Oct 24, 2007·Cell Biology International·Amelia ToescaRaffaele Sadun
Mar 8, 2008·Journal of the Neurological Sciences·Yuksel KaplanHatice Karaer
Feb 13, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shigeharu UchiyamaToshimitsu Momose
Mar 9, 2010·The Journal of Biological Chemistry·Ichiaki ItoJunn Yanagisawa
Apr 20, 2010·Annals of the New York Academy of Sciences·Stefano SoldanoMaurizio Cutolo
Sep 28, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jae Kwang KimJeong Suh Kim
Oct 20, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yu-Long SunPeter C Amadio
Aug 17, 2012·The Journal of Investigative Dermatology·Margaret MarkiewiczMaria Trojanowska
Jan 12, 2013·Arthritis Research & Therapy·Keiko Aida-YasuokaCarol A Feghali-Bostwick
Sep 10, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takako ChikenjiPeter C Amadio
Jul 31, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anne GingeryPeter C Amadio
Mar 16, 2017·Journal of Cellular Physiology·Yoshiaki YamanakaPeter C Amadio

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