Effect of estrogen on cell proliferation in colonic mucosa of the mouse

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
M B HoffK M Mak

Abstract

The effect of estrogen on cell proliferation in the descending colon of the mouse as an example of a non-target organ was investigated. Ovariectomized mice were given single or multiple injections of 10 ng/g body weight of 17 beta-estradiol and were killed 1 h after 3H-thymidine injection. Estrogen treatments decreased incorporation of 3H-thymidine into the DNA of colonic mucosa most markedly at 4 h after the single or the last of multiple injections. The inhibitory effect of estrogen on 3H-thymidine incorporation was greater and lasted longer after a single injection than after multiple ones. A similar inhibitory effect was observed in the colonic mucosa of male mice as well as in the mucosa of mice in which colonic epithelial cell proliferation was enhanced by refeeding after 48 h of fasting. However, the colonic mucosa of mice treated with estrogen implants for up to 4 days was not affected. Estrogen treatments caused no significant change in the DNA, RNA and protein contents of the colonic mucosa. The efficacy of estrogen treatments was verified by an increase in both the wet and dry weights of the uterine horns of ovariectomized mice.

References

Aug 1, 1972·The Journal of Endocrinology·A E Lee, L A Rogers
Mar 1, 1969·Analytical Biochemistry·R I Lin, O A Schjeide
Oct 1, 1965·Journal of Cellular Physiology·J GorskiJ A Nicolette
Jun 1, 1966·Experimental Cell Research·O I Epifanova
Jul 1, 1961·Endocrinology·P P DUKES, E GOLDWASSER

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Citations

Feb 7, 2001·Biochemical and Biophysical Research Communications·N AraiJ A Gustafsson
Jul 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·P SinghL Chicone
Jun 17, 2000·Infection and Immunity·B A MagnusonC J Hovde
Dec 1, 1995·Gut·S Singh, M J Langman
Oct 1, 1991·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·J B ParkD Oster
Nov 17, 2010·Histochemistry and Cell Biology·F Darío Cuello-CarriónErica L Kreimann
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·J R IzbickiH Troidl
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·J R IzbickiJ Kusche
Feb 28, 2004·Experimental Biology and Medicine·Yasuhiro KimuraRandal K Buddington
Jan 7, 2015·Steroids·Guillaume BouguenBenjamin Bertin
Nov 1, 1994·Molecular and Cellular Endocrinology·X Xu, M L Thomas

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